Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

K. Shankaran, Karla L. Donnelly, Shrenik K. Shah, Ravindra N. Guthikonda, Malcolm MacCoss, John L. Humes, Stephen G. Pacholok, Stephan K. Grant, T. M. Kelly, K. K. Wong

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.

Original languageEnglish
Pages (from-to)4539-4544
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number17
DOIs
StatePublished - 6 Sep 2004

Keywords

  • 1,3-Thiazolidin-2-imine
  • NOS
  • Pyrrolidin-2-imine

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