TY - JOUR
T1 - Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase
AU - Shankaran, K.
AU - Donnelly, Karla L.
AU - Shah, Shrenik K.
AU - Guthikonda, Ravindra N.
AU - MacCoss, Malcolm
AU - Humes, John L.
AU - Pacholok, Stephen G.
AU - Grant, Stephan K.
AU - Kelly, T. M.
AU - Wong, K. K.
PY - 2004/9/6
Y1 - 2004/9/6
N2 - Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.
AB - Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.
KW - 1,3-Thiazolidin-2-imine
KW - NOS
KW - Pyrrolidin-2-imine
UR - http://www.scopus.com/inward/record.url?scp=3843124407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3843124407&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2004.06.033
DO - 10.1016/j.bmcl.2004.06.033
M3 - Article
C2 - 15357988
AN - SCOPUS:3843124407
SN - 0960-894X
VL - 14
SP - 4539
EP - 4544
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 17
ER -