TY - JOUR
T1 - Exploring the multiphysics of the brain during development, aging, and in neurological diseases
AU - Weickenmeier, Johannes
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/1
Y1 - 2023/1
N2 - The human brain remains an endless source of wonder and represents an intruiging scientific frontier. Multiphysics approaches naturally lend themselves to combine our extensive knowledge about the neurobiology of aging and diseases with mechanics to better capture the multiscale behavior of the brain. Our group uses experimental methods, medical image analysis, and constitutive modeling to develop better disease models with the long-term goal to improve diagnosis, treatment, and ultimately enable prevention of many prevalent age- and disease-related brain changes. In the present perspective, we outline on-going work related to neurodevelopment, aging, and neurodegenerative disease.
AB - The human brain remains an endless source of wonder and represents an intruiging scientific frontier. Multiphysics approaches naturally lend themselves to combine our extensive knowledge about the neurobiology of aging and diseases with mechanics to better capture the multiscale behavior of the brain. Our group uses experimental methods, medical image analysis, and constitutive modeling to develop better disease models with the long-term goal to improve diagnosis, treatment, and ultimately enable prevention of many prevalent age- and disease-related brain changes. In the present perspective, we outline on-going work related to neurodevelopment, aging, and neurodegenerative disease.
KW - Brain aging
KW - Longitudinal medical image registration
KW - Mechanical testing
KW - Multiphysics brainmechanics
KW - Neurodegenerative disease
UR - http://www.scopus.com/inward/record.url?scp=85159478342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85159478342&partnerID=8YFLogxK
U2 - 10.1016/j.brain.2023.100068
DO - 10.1016/j.brain.2023.100068
M3 - Letter
AN - SCOPUS:85159478342
VL - 4
JO - Brain Multiphysics
JF - Brain Multiphysics
M1 - 100068
ER -