Exploring the multiphysics of the brain during development, aging, and in neurological diseases

Johannes Weickenmeier

doi:10.1016/j.brain.2023.100068

Exploring the multiphysics of the brain during development, aging, and in neurological diseases

Johannes Weickenmeier

Department of Mechanical Engineering

Research output: Contribution to journal › Letter › peer-review

4 Scopus citations

Abstract

The human brain remains an endless source of wonder and represents an intruiging scientific frontier. Multiphysics approaches naturally lend themselves to combine our extensive knowledge about the neurobiology of aging and diseases with mechanics to better capture the multiscale behavior of the brain. Our group uses experimental methods, medical image analysis, and constitutive modeling to develop better disease models with the long-term goal to improve diagnosis, treatment, and ultimately enable prevention of many prevalent age- and disease-related brain changes. In the present perspective, we outline on-going work related to neurodevelopment, aging, and neurodegenerative disease.

Original language	English
Article number	100068
Journal	Brain Multiphysics
Volume	4
DOIs	https://doi.org/10.1016/j.brain.2023.100068
State	Published - Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Brain aging
Longitudinal medical image registration
Mechanical testing
Multiphysics brainmechanics
Neurodegenerative disease

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10.1016/j.brain.2023.100068

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title = "Exploring the multiphysics of the brain during development, aging, and in neurological diseases",

abstract = "The human brain remains an endless source of wonder and represents an intruiging scientific frontier. Multiphysics approaches naturally lend themselves to combine our extensive knowledge about the neurobiology of aging and diseases with mechanics to better capture the multiscale behavior of the brain. Our group uses experimental methods, medical image analysis, and constitutive modeling to develop better disease models with the long-term goal to improve diagnosis, treatment, and ultimately enable prevention of many prevalent age- and disease-related brain changes. In the present perspective, we outline on-going work related to neurodevelopment, aging, and neurodegenerative disease.",

keywords = "Brain aging, Longitudinal medical image registration, Mechanical testing, Multiphysics brainmechanics, Neurodegenerative disease",

author = "Johannes Weickenmeier",

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year = "2023",

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doi = "10.1016/j.brain.2023.100068",

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AU - Weickenmeier, Johannes

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AB - The human brain remains an endless source of wonder and represents an intruiging scientific frontier. Multiphysics approaches naturally lend themselves to combine our extensive knowledge about the neurobiology of aging and diseases with mechanics to better capture the multiscale behavior of the brain. Our group uses experimental methods, medical image analysis, and constitutive modeling to develop better disease models with the long-term goal to improve diagnosis, treatment, and ultimately enable prevention of many prevalent age- and disease-related brain changes. In the present perspective, we outline on-going work related to neurodevelopment, aging, and neurodegenerative disease.

KW - Brain aging

KW - Longitudinal medical image registration

KW - Mechanical testing

KW - Multiphysics brainmechanics

KW - Neurodegenerative disease

UR - https://www.scopus.com/pages/publications/85159478342

UR - https://www.scopus.com/pages/publications/85159478342#tab=citedBy

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DO - 10.1016/j.brain.2023.100068

M3 - Letter

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VL - 4

JO - Brain Multiphysics

JF - Brain Multiphysics

M1 - 100068

ER -

Exploring the multiphysics of the brain during development, aging, and in neurological diseases

Abstract

UN SDGs

Keywords

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