Extracting three-dimensional orientation and tractography of myofibers using optical coherence tomography

Yu Gan, Christine P. Fleming

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Abnormal changes in orientation of myofibers are associated with various cardiac diseases such as arrhythmia, irregular contraction, and cardiomyopathy. To extract fiber information, we present a method of quantifying fiber orientation and reconstructing three-dimensional tractography of myofibers using optical coherence tomography (OCT). A gradient based algorithm was developed to quantify fiber orientation in three dimensions and particle filtering technique was employed to track myofibers. Prior to image processing, three-dimensional image data set were acquired from all cardiac chambers and ventricular septum of swine hearts using OCT system without optical clearing. The algorithm was validated through rotation test and comparison with manual measurements. The experimental results demonstrate that we are able to visualize threedimensional fiber tractography in myocardium tissues.

Original languageEnglish
Pages (from-to)2150-2165
Number of pages16
JournalBiomedical Optics Express
Volume4
Issue number10
DOIs
StatePublished - 2013

Fingerprint

Dive into the research topics of 'Extracting three-dimensional orientation and tractography of myofibers using optical coherence tomography'. Together they form a unique fingerprint.

Cite this