TY - JOUR
T1 - Extracting three-dimensional orientation and tractography of myofibers using optical coherence tomography
AU - Gan, Yu
AU - Fleming, Christine P.
PY - 2013
Y1 - 2013
N2 - Abnormal changes in orientation of myofibers are associated with various cardiac diseases such as arrhythmia, irregular contraction, and cardiomyopathy. To extract fiber information, we present a method of quantifying fiber orientation and reconstructing three-dimensional tractography of myofibers using optical coherence tomography (OCT). A gradient based algorithm was developed to quantify fiber orientation in three dimensions and particle filtering technique was employed to track myofibers. Prior to image processing, three-dimensional image data set were acquired from all cardiac chambers and ventricular septum of swine hearts using OCT system without optical clearing. The algorithm was validated through rotation test and comparison with manual measurements. The experimental results demonstrate that we are able to visualize threedimensional fiber tractography in myocardium tissues.
AB - Abnormal changes in orientation of myofibers are associated with various cardiac diseases such as arrhythmia, irregular contraction, and cardiomyopathy. To extract fiber information, we present a method of quantifying fiber orientation and reconstructing three-dimensional tractography of myofibers using optical coherence tomography (OCT). A gradient based algorithm was developed to quantify fiber orientation in three dimensions and particle filtering technique was employed to track myofibers. Prior to image processing, three-dimensional image data set were acquired from all cardiac chambers and ventricular septum of swine hearts using OCT system without optical clearing. The algorithm was validated through rotation test and comparison with manual measurements. The experimental results demonstrate that we are able to visualize threedimensional fiber tractography in myocardium tissues.
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U2 - 10.1364/BOE.4.002150
DO - 10.1364/BOE.4.002150
M3 - Article
AN - SCOPUS:84884929867
VL - 4
SP - 2150
EP - 2165
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 10
ER -