@inproceedings{ad59a0d07d4648c3a1d67fa587798ff7,
title = "Fiber optic probe enabled by surface-enhanced Raman scattering for early diagnosis of potential acute rejection of kidney transplant",
abstract = "We have explored the use of a fiber-optic probe with surface-enhanced Raman scattering (SERS) sensing modality for early, noninvasive and, rapid diagnosis of potential renal acute rejection (AR) and other renal graft dysfunction of kidney transplant patients. Multimode silica optical fiber immobilized with colloidal Ag nanoparticles at the distal end was used for SERS measurements of as-collected urine samples at 632.8 nm excitation wavelength. All patients with abnormal renal graft function (3 AR episodes and 2 graft failure episodes) who were clinically diagnosed independently show common unique SERS spectral features in the urines collected just one day after transplant. SERS-based fiber-optic probe has excellent potential to be a bedside tool for early diagnosis of kidney transplant patients for timely medical intervention of patients at high risk of transplant dysfunction.",
keywords = "SERS, acute rejection, fiber optic, kidney transplant, urine",
author = "Jingmao Chi and Hui Chen and Peter Tolias and Henry Du",
year = "2014",
doi = "10.1117/12.2054976",
language = "English",
isbn = "9781628410358",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
booktitle = "Fiber Optic Sensors and Applications XI",
note = "Fiber Optic Sensors and Applications XI ; Conference date: 08-05-2014 Through 09-05-2014",
}