Fiber optic probe enabled by surface-enhanced Raman scattering for early diagnosis of potential acute rejection of kidney transplant

Jingmao Chi, Hui Chen, Peter Tolias, Henry Du

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

We have explored the use of a fiber-optic probe with surface-enhanced Raman scattering (SERS) sensing modality for early, noninvasive and, rapid diagnosis of potential renal acute rejection (AR) and other renal graft dysfunction of kidney transplant patients. Multimode silica optical fiber immobilized with colloidal Ag nanoparticles at the distal end was used for SERS measurements of as-collected urine samples at 632.8 nm excitation wavelength. All patients with abnormal renal graft function (3 AR episodes and 2 graft failure episodes) who were clinically diagnosed independently show common unique SERS spectral features in the urines collected just one day after transplant. SERS-based fiber-optic probe has excellent potential to be a bedside tool for early diagnosis of kidney transplant patients for timely medical intervention of patients at high risk of transplant dysfunction.

Original languageEnglish
Title of host publicationFiber Optic Sensors and Applications XI
DOIs
StatePublished - 2014
EventFiber Optic Sensors and Applications XI - Baltimore, MD, United States
Duration: 8 May 20149 May 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9098
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceFiber Optic Sensors and Applications XI
Country/TerritoryUnited States
CityBaltimore, MD
Period8/05/149/05/14

Keywords

  • SERS
  • acute rejection
  • fiber optic
  • kidney transplant
  • urine

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