Fibrin membrane endowed with biological function VI. Immobilization of multienzymes of urea cycle

Yuji Inada, Yukio Tazawa, Attula Attygalle, Yuji Saito

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Four enzymes in urea cycle and inorganic pyrophosphatase were immobilized simultaneously into a matrix of fibrin fiber formed from fibrinogen by the concerted action of thrombin and blood coagulation Factor XIII. The immobilized multienzyme system not only had an ability to carry out urea cycle continuously at least over several hours, but also had a greatly improved efficiency over the corresponding soluble system.

Original languageEnglish
Pages (from-to)1586-1591
Number of pages6
JournalTopics in Catalysis
Volume96
Issue number4
DOIs
StatePublished - 1980

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