Functionalization of nanofibrous spiral structured scaffolds for bone tissue engineering

Junping Wang, Xiaojun Yu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In the previous studies, we have successfully developed a novel spiral structured nanofibrous scaffolds with improved osteoconductivity for bone tissue engineering1. The spiral structure design facilitates the nutrient transport and waste removal, and allows uniform cellular growth and distribution within the scaffolds, thus enhanced the bioactivity of the scaffolds. In this chapter, HAP and BMP-2 were incorporated within the nanofibrous spiral scaffolds in order to enhance the osteoinductivity of the established system. The effect of the blending materials was evaluated through cell proliferation, cell differentiation of human osteoblast cells seeded on the scaffolds and cultured for 4 and 8 days. The results has demonstrated that the functionalization of PCL nanofibrous spiral scaffolds leads to higher ALP expression level and increased amount of mineralization level however lower cell proliferation rate.

Original languageEnglish
Title of host publicationEngineering Biomaterials for Regenerative Medicine
Pages38-43
Number of pages6
StatePublished - 2010
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: 30 Nov 20094 Dec 2009

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1235
ISSN (Print)0272-9172

Conference

Conference2009 MRS Fall Meeting
Country/TerritoryUnited States
CityBoston, MA
Period30/11/094/12/09

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