Functionally graded β-TCP/PCL nanocomposite scaffolds: In vitro evaluation with human fetal osteoblast cells for bone tissue engineering

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Abstract

The engineering of biomimetic tissue relies on the ability to develop biodegradable scaffolds with functionally graded physical and chemical properties. In this study, a twin-screw-extrusion/spiral winding (TSESW) process was developed to enable the radial grading of porous scaffolds (discrete and continuous gradations) that were composed of polycaprolactone (PCL), β-tricalcium-phosphate (β-TCP) nanoparticles, and salt porogens. Scaffolds with interconnected porosity, exhibiting myriad radial porosity, pore-size distributions, and β-TCP nanoparticle concentration could be obtained. The results of the characterization of their compressive properties and in vitro cell proliferation studies using human fetal osteoblast cells suggest the promising nature of such scaffolds. The significant degree of freedom offered by the TSESW process should be an additional enabler in the quest toward the mimicry of the complex elegance of the native tissues.

Original languageEnglish
Pages (from-to)1007-1018
Number of pages12
JournalJournal of Biomedical Materials Research - Part A
Volume92
Issue number3
DOIs
StatePublished - 1 Mar 2010

Keywords

  • Extrusion
  • Functionally graded
  • Nanocomposite
  • Osteoblast
  • Scaffold
  • Tissue engineering

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