TY - JOUR
T1 - Functionally graded β-TCP/PCL nanocomposite scaffolds
T2 - In vitro evaluation with human fetal osteoblast cells for bone tissue engineering
AU - Ozkan, Seher
AU - Kalyon, Dilhan M.
AU - Yu, Xiaojun
PY - 2010/3/1
Y1 - 2010/3/1
N2 - The engineering of biomimetic tissue relies on the ability to develop biodegradable scaffolds with functionally graded physical and chemical properties. In this study, a twin-screw-extrusion/spiral winding (TSESW) process was developed to enable the radial grading of porous scaffolds (discrete and continuous gradations) that were composed of polycaprolactone (PCL), β-tricalcium-phosphate (β-TCP) nanoparticles, and salt porogens. Scaffolds with interconnected porosity, exhibiting myriad radial porosity, pore-size distributions, and β-TCP nanoparticle concentration could be obtained. The results of the characterization of their compressive properties and in vitro cell proliferation studies using human fetal osteoblast cells suggest the promising nature of such scaffolds. The significant degree of freedom offered by the TSESW process should be an additional enabler in the quest toward the mimicry of the complex elegance of the native tissues.
AB - The engineering of biomimetic tissue relies on the ability to develop biodegradable scaffolds with functionally graded physical and chemical properties. In this study, a twin-screw-extrusion/spiral winding (TSESW) process was developed to enable the radial grading of porous scaffolds (discrete and continuous gradations) that were composed of polycaprolactone (PCL), β-tricalcium-phosphate (β-TCP) nanoparticles, and salt porogens. Scaffolds with interconnected porosity, exhibiting myriad radial porosity, pore-size distributions, and β-TCP nanoparticle concentration could be obtained. The results of the characterization of their compressive properties and in vitro cell proliferation studies using human fetal osteoblast cells suggest the promising nature of such scaffolds. The significant degree of freedom offered by the TSESW process should be an additional enabler in the quest toward the mimicry of the complex elegance of the native tissues.
KW - Extrusion
KW - Functionally graded
KW - Nanocomposite
KW - Osteoblast
KW - Scaffold
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=75749089257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75749089257&partnerID=8YFLogxK
U2 - 10.1002/jbm.a.32425
DO - 10.1002/jbm.a.32425
M3 - Article
C2 - 19296543
AN - SCOPUS:75749089257
SN - 1549-3296
VL - 92
SP - 1007
EP - 1018
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
IS - 3
ER -