Hepatocytes cultured on lactose-substituted polystyrene become resistant to cytokine-induced cellular injury

Jun F. Liang, Toshihiro Akaike

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Responses of hepatocytes on various extracellular matrices to injury by cytokine and endotoxin were studied. Hepatocytes cultured on poly-N-p-vinylbenzyl-D-lactonamide (PVLA) surfaces became resistant to IFN γ-induced cell injury and also resisted the stimulation from endotoxin and cytokines, and thus showed low nitric oxide synthesis ability. Damage to transplanted cell in engineered tissue/organ can thus be prevented by culturing cells on appropriate synthetic extracellular matrices.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalBiotechnology Letters
Volume20
Issue number2
DOIs
StatePublished - 1998

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