Abstract
Responses of hepatocytes on various extracellular matrices to injury by cytokine and endotoxin were studied. Hepatocytes cultured on poly-N-p-vinylbenzyl-D-lactonamide (PVLA) surfaces became resistant to IFN γ-induced cell injury and also resisted the stimulation from endotoxin and cytokines, and thus showed low nitric oxide synthesis ability. Damage to transplanted cell in engineered tissue/organ can thus be prevented by culturing cells on appropriate synthetic extracellular matrices.
Original language | English |
---|---|
Pages (from-to) | 173-176 |
Number of pages | 4 |
Journal | Biotechnology Letters |
Volume | 20 |
Issue number | 2 |
DOIs | |
State | Published - 1998 |