Hepatocytes cultured on lactose-substituted polystyrene become resistant to cytokine-induced cellular injury

Jun F. Liang; Toshihiro Akaike

doi:10.1023/A:1005336710044

Hepatocytes cultured on lactose-substituted polystyrene become resistant to cytokine-induced cellular injury

Jun F. Liang, Toshihiro Akaike

Department of Chemistry and Chemical Biology

Tokyo Institute of Technology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Responses of hepatocytes on various extracellular matrices to injury by cytokine and endotoxin were studied. Hepatocytes cultured on poly-N-p-vinylbenzyl-D-lactonamide (PVLA) surfaces became resistant to IFN γ-induced cell injury and also resisted the stimulation from endotoxin and cytokines, and thus showed low nitric oxide synthesis ability. Damage to transplanted cell in engineered tissue/organ can thus be prevented by culturing cells on appropriate synthetic extracellular matrices.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Biotechnology Letters
Volume	20
Issue number	2
DOIs	https://doi.org/10.1023/A:1005336710044
State	Published - 1998

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title = "Hepatocytes cultured on lactose-substituted polystyrene become resistant to cytokine-induced cellular injury",

abstract = "Responses of hepatocytes on various extracellular matrices to injury by cytokine and endotoxin were studied. Hepatocytes cultured on poly-N-p-vinylbenzyl-D-lactonamide (PVLA) surfaces became resistant to IFN γ-induced cell injury and also resisted the stimulation from endotoxin and cytokines, and thus showed low nitric oxide synthesis ability. Damage to transplanted cell in engineered tissue/organ can thus be prevented by culturing cells on appropriate synthetic extracellular matrices.",

author = "Liang, \{Jun F.\} and Toshihiro Akaike",

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T1 - Hepatocytes cultured on lactose-substituted polystyrene become resistant to cytokine-induced cellular injury

AU - Liang, Jun F.

AU - Akaike, Toshihiro

PY - 1998

Y1 - 1998

N2 - Responses of hepatocytes on various extracellular matrices to injury by cytokine and endotoxin were studied. Hepatocytes cultured on poly-N-p-vinylbenzyl-D-lactonamide (PVLA) surfaces became resistant to IFN γ-induced cell injury and also resisted the stimulation from endotoxin and cytokines, and thus showed low nitric oxide synthesis ability. Damage to transplanted cell in engineered tissue/organ can thus be prevented by culturing cells on appropriate synthetic extracellular matrices.

AB - Responses of hepatocytes on various extracellular matrices to injury by cytokine and endotoxin were studied. Hepatocytes cultured on poly-N-p-vinylbenzyl-D-lactonamide (PVLA) surfaces became resistant to IFN γ-induced cell injury and also resisted the stimulation from endotoxin and cytokines, and thus showed low nitric oxide synthesis ability. Damage to transplanted cell in engineered tissue/organ can thus be prevented by culturing cells on appropriate synthetic extracellular matrices.

UR - https://www.scopus.com/pages/publications/0031932088

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U2 - 10.1023/A:1005336710044

DO - 10.1023/A:1005336710044

M3 - Article

AN - SCOPUS:0031932088

SN - 0141-5492

VL - 20

SP - 173

EP - 176

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 2

ER -

Hepatocytes cultured on lactose-substituted polystyrene become resistant to cytokine-induced cellular injury

Abstract

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