Abstract
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.
Original language | English |
---|---|
Pages (from-to) | 661-666 |
Number of pages | 6 |
Journal | Nature |
Volume | 381 |
Issue number | 6584 |
DOIs | |
State | Published - 1996 |