Identification of a major co-receptor for primary isolates of HIV-1

Hong Kui Deng, Rong Liu, Wilfried Ellmeier, Sunny Choe, Derya Unutmaz, Michael Burkhart, Paola Di Marzio, Shoshana Marmon, Richard E. Sutton, C. Mark Hill, Craig B. Davis, Stephen C. Peiper, Thomas J. Schall, Dan R. Littman, Nathaniel R. Landau

Research output: Contribution to journalArticlepeer-review

3265 Scopus citations

Abstract

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.

Original languageEnglish
Pages (from-to)661-666
Number of pages6
JournalNature
Volume381
Issue number6584
DOIs
StatePublished - 1996

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