Identification of a major co-receptor for primary isolates of HIV-1

Hong Kui Deng; Rong Liu; Wilfried Ellmeier; Sunny Choe; Derya Unutmaz; Michael Burkhart; Paola Di Marzio; Shoshana Marmon; Richard E. Sutton; C. Mark Hill; Craig B. Davis; Stephen C. Peiper; Thomas J. Schall; Dan R. Littman; Nathaniel R. Landau

doi:10.1038/381661a0

Identification of a major co-receptor for primary isolates of HIV-1

Hong Kui Deng, Rong Liu, Wilfried Ellmeier, Sunny Choe, Derya Unutmaz, Michael Burkhart, Paola Di Marzio, Shoshana Marmon, Richard E. Sutton, C. Mark Hill, Craig B. Davis, Stephen C. Peiper, Thomas J. Schall, Dan R. Littman, Nathaniel R. Landau

Department of Chemistry and Chemical Biology

Research output: Contribution to journal › Article › peer-review

3298 Scopus citations

Abstract

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.

Original language	English
Pages (from-to)	661-666
Number of pages	6
Journal	Nature
Volume	381
Issue number	6584
DOIs	https://doi.org/10.1038/381661a0
State	Published - 1996

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@article{ee664bd9c81d449b8639556ef63e1bba,

title = "Identification of a major co-receptor for primary isolates of HIV-1",

abstract = "Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.",

author = "Deng, \{Hong Kui\} and Rong Liu and Wilfried Ellmeier and Sunny Choe and Derya Unutmaz and Michael Burkhart and \{Di Marzio\}, Paola and Shoshana Marmon and Sutton, \{Richard E.\} and \{Mark Hill\}, C. and Davis, \{Craig B.\} and Peiper, \{Stephen C.\} and Schall, \{Thomas J.\} and Littman, \{Dan R.\} and Landau, \{Nathaniel R.\}",

year = "1996",

doi = "10.1038/381661a0",

language = "English",

volume = "381",

pages = "661--666",

number = "6584",

}

TY - JOUR

T1 - Identification of a major co-receptor for primary isolates of HIV-1

AU - Deng, Hong Kui

AU - Liu, Rong

AU - Ellmeier, Wilfried

AU - Choe, Sunny

AU - Unutmaz, Derya

AU - Burkhart, Michael

AU - Di Marzio, Paola

AU - Marmon, Shoshana

AU - Sutton, Richard E.

AU - Mark Hill, C.

AU - Davis, Craig B.

AU - Peiper, Stephen C.

AU - Schall, Thomas J.

AU - Littman, Dan R.

AU - Landau, Nathaniel R.

PY - 1996

Y1 - 1996

N2 - Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.

AB - Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.

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U2 - 10.1038/381661a0

DO - 10.1038/381661a0

M3 - Article

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AN - SCOPUS:15844419153

SN - 0028-0836

VL - 381

SP - 661

EP - 666

JO - Nature

JF - Nature

IS - 6584

ER -

Identification of a major co-receptor for primary isolates of HIV-1

Abstract

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