Improved dialysis technique for core-shell pullulan-polycaprolactone (PCL) nanospheres loaded with hydrophobic ciprofloxacin

Sally F. Shady-Elghamrawi, Daniel F. Schmidt, Stephen P. McCarthy

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Drug delivery vehicles such as nanospheres improve solubility, bioavailability and biodistribution of many pharmaceutical drugs. Low encapsulation efficiency is a limitation that currently challenges many drug carriers. The dialysis method can be used as a technique to address this problem and enhance the purity and consistency of the materials being prepared. This research demonstrates the encapsulation of hydrophobic ciprofloxacin in Pullulan- Polycaprolactone (PCL) core-shell nanospheres and investigates dialysis times at 24, 48 and 72 hours with and without the addition of ciprofloxacin in the dialysis water. UV spectroscopy showed that the addition of ciprofloxacin to the water used to dialyze loaded nanospheres resulted in the retention of approximately 30-40 times more drugs than the case where loaded nanospheres were dialyzed with pure water. This was also confirmed with release data tested under specified in vitro conditions. The 72 hour groups appeared the most pure, as evidenced by color and texture. Such findings demonstrate an improved dialysis method which can be utilized to enhance drug encapsulation as well as the physical appearance of the loaded nanospheres.

Original languageEnglish
Title of host publication69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
Pages1982-1988
Number of pages7
StatePublished - 2011
Event69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011 - Boston, MA, United States
Duration: 1 May 20115 May 2011

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume3

Conference

Conference69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
Country/TerritoryUnited States
CityBoston, MA
Period1/05/115/05/11

Keywords

  • Ciprofloxacin
  • Dialysis
  • Nanospheres
  • Polycaprolactone (PCL)
  • Pullulan

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