@inproceedings{f5a73502f29345528e0e5a4560fdc2d1,
title = "In-situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers under static and dynamic conditions",
abstract = "The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA]n polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA]n and a measurement probe for GS release. We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a range of dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multilayer interface. The LOF platform has the potential to be a powerful test bed to facilitate the design and evaluation of drug-eluting polyelectrolyte thin films for their clinical insertion as part of patient care strategy.",
keywords = "Long period grating, drug release, dynamic, gentamicin sulfate, lab on fiber, polyelectrolyte, thin film",
author = "Fei Tian and Jouha Min and Jiri Kanka and Hammond, {Paula T.} and Henry Du",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Fiber Optic Sensors and Applications XII ; Conference date: 22-04-2015 Through 23-04-2015",
year = "2015",
doi = "10.1117/12.2191683",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
editor = "Du, {Henry H.} and Gary Pickrell and Eric Udd",
booktitle = "Fiber Optic Sensors and Applications XII",
}