In-situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers under static and dynamic conditions

Fei Tian, Jouha Min, Jiri Kanka, Paula T. Hammond, Henry Du

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA]n polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA]n and a measurement probe for GS release. We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a range of dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multilayer interface. The LOF platform has the potential to be a powerful test bed to facilitate the design and evaluation of drug-eluting polyelectrolyte thin films for their clinical insertion as part of patient care strategy.

Original languageEnglish
Title of host publicationFiber Optic Sensors and Applications XII
EditorsHenry H. Du, Gary Pickrell, Eric Udd
ISBN (Electronic)9781628415964
DOIs
StatePublished - 2015
EventFiber Optic Sensors and Applications XII - Baltimore, United States
Duration: 22 Apr 201523 Apr 2015

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9480
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceFiber Optic Sensors and Applications XII
Country/TerritoryUnited States
CityBaltimore
Period22/04/1523/04/15

Keywords

  • Long period grating
  • drug release
  • dynamic
  • gentamicin sulfate
  • lab on fiber
  • polyelectrolyte
  • thin film

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