Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D

Laura D. Gegnas, Sherman T. Waddell, Renee M. Chabin, Sreelatha Reddy, Kenny K. Wong

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

A series of transition-state analog inhibitors of the D-glutamic acid- adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.

Original languageEnglish
Pages (from-to)1643-1648
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number13
DOIs
StatePublished - 7 Jul 1998

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