Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D

Laura D. Gegnas; Sherman T. Waddell; Renee M. Chabin; Sreelatha Reddy; Kenny K. Wong

doi:10.1016/S0960-894X(98)00285-6

Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D

Laura D. Gegnas
, Sherman T. Waddell
, Renee M. Chabin
, Sreelatha Reddy
, Kenny K. Wong

Department of Chemistry and Chemical Biology

Merck

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A series of transition-state analog inhibitors of the D-glutamic acid- adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.

Original language	English
Pages (from-to)	1643-1648
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(98)00285-6
State	Published - 7 Jul 1998

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title = "Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D",

abstract = "A series of transition-state analog inhibitors of the D-glutamic acid- adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.",

author = "Gegnas, \{Laura D.\} and Waddell, \{Sherman T.\} and Chabin, \{Renee M.\} and Sreelatha Reddy and Wong, \{Kenny K.\}",

year = "1998",

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AU - Gegnas, Laura D.

AU - Waddell, Sherman T.

AU - Chabin, Renee M.

AU - Reddy, Sreelatha

AU - Wong, Kenny K.

PY - 1998/7/7

Y1 - 1998/7/7

N2 - A series of transition-state analog inhibitors of the D-glutamic acid- adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.

AB - A series of transition-state analog inhibitors of the D-glutamic acid- adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.

UR - https://www.scopus.com/pages/publications/0032493338

UR - https://www.scopus.com/pages/publications/0032493338#tab=citedBy

U2 - 10.1016/S0960-894X(98)00285-6

DO - 10.1016/S0960-894X(98)00285-6

M3 - Article

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AN - SCOPUS:0032493338

SN - 0960-894X

VL - 8

SP - 1643

EP - 1648

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D

Abstract

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