Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency

Jun F. Liang, Victor C. Yang

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

Cell-penetrating peptide (CPP) was linked to insulin to form insulin-CPP hybrids. The intestinal absorption efficiency of CPP hybridized insulin was 6-8 times increased compared to normal insulin as tested on Caco-2 cell monolayer, a widely used in vitro model for intestinal absorption. Insulin-CPP hybrid transportation seemed to be through an active and transcytosis-like mechanism. Importantly, insulin in hybrids kept intact after they passed through the Caco-2 cell monolayer. This study provides a new clue for oral insulin development.

Original languageEnglish
Pages (from-to)734-738
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume335
Issue number3
DOIs
StatePublished - 30 Sep 2005

Keywords

  • Caco-2 cell monolayer
  • Cell-penetrating peptide
  • Diabetes
  • Drug delivery
  • Oral insulin
  • TAT

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