Integrating aptamers and microfluidics for biological manipulation and sensing

Qiao Lin, Jinho Kim, Jing Zhu, Jaeyoung Yang, John Hilton, Thaihuu Nguyen, Renjun Pei, Kyung Ae Yang, Milan Stojanovic

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present an overview of our efforts to integrate aptamers and microfluidic devices, including manipulation of biomolecules and cells using aptamers, and isolation of target-binding nucleic acids. The aptamer-based devices for target manipulation are capable of specific analyte extraction and enrichment as well as isocratic elution, and can be coupled to biodetection systems for highly sensitive analyte detection. The microfluidic devices for isolation of target-binding nucleic acids demonstrate the potential for integrated selection of aptamers having predefined binding characteristics against a broad spectrum of practically important biological analytes.

Original languageEnglish
Title of host publication8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Pages1245-1248
Number of pages4
DOIs
StatePublished - 2013
Event8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 - Suzhou, China
Duration: 7 Apr 201310 Apr 2013

Publication series

Name8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013

Conference

Conference8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Country/TerritoryChina
CitySuzhou
Period7/04/1310/04/13

Keywords

  • aptamer
  • detection
  • enrichment
  • extraction
  • microfluidic

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