Mapping the human atria with optical coherence tomography

Theresa H. Lye, Yu Gan, Christine P. Hendon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Atrial structure plays an important role in the mechanisms of atrial disease. However, detailed imaging of human atria remains limited due to many imaging modalities lacking sufficient resolution. We propose the use of optical coherence tomography (OCT), which has micrometer resolution and millimeter-scale imaging depth well-suited for the atria, combined with image stitching algorithms, to develop large, detailed atria image maps. Human atria samples (n = 7) were obtained under approved protocols from the National Disease Research Interchange (NDRI). One right atria sample was imaged using an ultrahigh-resolution spectral domain OCT system, with 5.52 and 2.72 μm lateral and axial resolution in air, respectively, and 1.78 mm imaging depth. Six left atria and five pulmonary vein samples were imaged using the spectral domain OCT system, Telesto I (Thorlabs GmbH, Germany) with 15 and 6.5 μm lateral and axial resolution in air, respectively, and 2.51 mm imaging depth. Overlapping image volumes were obtained from areas of the human left and right atria and the pulmonary veins. Regions of collagen, adipose, and myocardium could be identified within the OCT images. Image stitching was applied to generate fields of view with side dimensions up to about 3 cm. This study established steps towards mapping large regions of the human atria and pulmonary veins in high resolution using OCT.

Original languageEnglish
Title of host publicationDiagnostic and Therapeutic Applications of Light in Cardiology
EditorsLaura Marcu, Guillermo J. Tearney, Kenton W. Gregory
ISBN (Electronic)9781510605251
DOIs
StatePublished - 2017
EventDiagnostic and Therapeutic Applications of Light in Cardiology - San Francisco, United States
Duration: 28 Jan 201729 Jan 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10042
ISSN (Print)1605-7422

Conference

ConferenceDiagnostic and Therapeutic Applications of Light in Cardiology
Country/TerritoryUnited States
CitySan Francisco
Period28/01/1729/01/17

Keywords

  • Optical coherence tomography
  • atria
  • image registration
  • pulmonary veins

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