TY - GEN
T1 - Mapping the human atria with optical coherence tomography
AU - Lye, Theresa H.
AU - Gan, Yu
AU - Hendon, Christine P.
N1 - Publisher Copyright:
© 2017 SPIE.
PY - 2017
Y1 - 2017
N2 - Atrial structure plays an important role in the mechanisms of atrial disease. However, detailed imaging of human atria remains limited due to many imaging modalities lacking sufficient resolution. We propose the use of optical coherence tomography (OCT), which has micrometer resolution and millimeter-scale imaging depth well-suited for the atria, combined with image stitching algorithms, to develop large, detailed atria image maps. Human atria samples (n = 7) were obtained under approved protocols from the National Disease Research Interchange (NDRI). One right atria sample was imaged using an ultrahigh-resolution spectral domain OCT system, with 5.52 and 2.72 μm lateral and axial resolution in air, respectively, and 1.78 mm imaging depth. Six left atria and five pulmonary vein samples were imaged using the spectral domain OCT system, Telesto I (Thorlabs GmbH, Germany) with 15 and 6.5 μm lateral and axial resolution in air, respectively, and 2.51 mm imaging depth. Overlapping image volumes were obtained from areas of the human left and right atria and the pulmonary veins. Regions of collagen, adipose, and myocardium could be identified within the OCT images. Image stitching was applied to generate fields of view with side dimensions up to about 3 cm. This study established steps towards mapping large regions of the human atria and pulmonary veins in high resolution using OCT.
AB - Atrial structure plays an important role in the mechanisms of atrial disease. However, detailed imaging of human atria remains limited due to many imaging modalities lacking sufficient resolution. We propose the use of optical coherence tomography (OCT), which has micrometer resolution and millimeter-scale imaging depth well-suited for the atria, combined with image stitching algorithms, to develop large, detailed atria image maps. Human atria samples (n = 7) were obtained under approved protocols from the National Disease Research Interchange (NDRI). One right atria sample was imaged using an ultrahigh-resolution spectral domain OCT system, with 5.52 and 2.72 μm lateral and axial resolution in air, respectively, and 1.78 mm imaging depth. Six left atria and five pulmonary vein samples were imaged using the spectral domain OCT system, Telesto I (Thorlabs GmbH, Germany) with 15 and 6.5 μm lateral and axial resolution in air, respectively, and 2.51 mm imaging depth. Overlapping image volumes were obtained from areas of the human left and right atria and the pulmonary veins. Regions of collagen, adipose, and myocardium could be identified within the OCT images. Image stitching was applied to generate fields of view with side dimensions up to about 3 cm. This study established steps towards mapping large regions of the human atria and pulmonary veins in high resolution using OCT.
KW - Optical coherence tomography
KW - atria
KW - image registration
KW - pulmonary veins
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U2 - 10.1117/12.2251048
DO - 10.1117/12.2251048
M3 - Conference contribution
AN - SCOPUS:85019119091
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Diagnostic and Therapeutic Applications of Light in Cardiology
A2 - Marcu, Laura
A2 - Tearney, Guillermo J.
A2 - Gregory, Kenton W.
T2 - Diagnostic and Therapeutic Applications of Light in Cardiology
Y2 - 28 January 2017 through 29 January 2017
ER -