Mathematical modeling and experimental investigations of crystallization and recrystallization processes to achieve targeted polymorphs and crystal size and shape distributions

The recrystallization of various nitramines to form different polymorphs can be investigated by employing computations [1] and/or experimental analyses. Microcrystallization, the analysis of polymorphs using X-ray powder diffraction and Rietveld analysis, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), polarized microscopy, and scanning electron microscopy (SEM) [2] are some of the available experimental analysis methods. The defect types and densities can also be characterized as shown for CL-20 [3].