Mechanical forces in musculoskeletal tissue engineering

P. Lee, M. McAree, W. Chang, X. Yu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations

Abstract

In tissue engineering, mechanical forces play two different roles: One role is to manipulate the behavior of cells by mechanotransduction via mechanical stimuli, whereas the other is presented in the various mechanical properties of different types of tissue. The mechanical stimulus has been shown to control cellular proliferation, differentiation, cell orientation, and apoptosis through different cell signaling pathways. These interactions can affect the production of extracellular matrix and eventual regeneration of tissue properties. Bioreactors have shown promise in being able to apply biologically related mechanical stresses, such as compression, tension, and shear, thus affecting stem cell differentiation. Through different conditions, several tissues have been developed and maintained, such as cartilage and bone. Associated with these tissues is the ability to exhibit resistance to different mechanical forces, such as compression. Currently, much research effort is being expended on applying mechanical stimulus to the physical environment in which cells and tissues are being incubated and guided into the desired phenotype. When regenerating tissue, if specific mechanical resistance is not met, tissue failure due to physiological stresses is highly possible.

Original languageEnglish
Title of host publicationRegenerative Engineering of Musculoskeletal Tissues and Interfaces
Pages77-93
Number of pages17
ISBN (Electronic)9781782423140
DOIs
StatePublished - 23 Apr 2015

Keywords

  • Bone
  • Cartilage
  • Musculoskeletal
  • Tissue engineering

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