Microchannel for intraocular pressure relief and glaucoma treatment

D. Barth, J. Heureaux, B. Pilapil, P. Ponce De Leon, K. Zhao, E. H. Yang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

In this paper the deisgn, modeling, fabrication, and testing of an PDMS microchannel intended as an ocular implant for the maintanance of healthy intraocular pressure (IOP) and treatment of glaucoma are described. The winding serpentine microchannel provides a minimally invasive pathway for fluid to travel from the anterior chamber to the exterior of the eye. Analytical modeling using a friction factor correlated to channel cross section and FEM simulations predicted a pressure drop across the device around 2 kPa at the typical eye fluid production rate of 2 μL/min. A mm-scale and various μm-scale prototypes were fabricated by pouring and curing PDMS onto Su-8 molds patterned by photolithography. The pressure difference across the channel, which was designed to have a pressure drop of 2 kPa, was measured to be 1.47 kPa.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages524-527
Number of pages4
StatePublished - 2011
EventNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: 13 Jun 201116 Jun 2011

Publication series

NameTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume2

Conference

ConferenceNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Country/TerritoryUnited States
CityBoston, MA
Period13/06/1116/06/11

Keywords

  • Glaucoma
  • MEMS
  • Microchannel
  • PDMS

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