TY - GEN
T1 - Microchannel reactor system for catalytic hydrogenation of o-nitroanisole to o-anisidine
AU - Lawal, Adeniyi
AU - Kientzler, Donald
AU - Achenie, Luke
AU - Halder, Raghunath
AU - Besser, Ronald S.
AU - Tadepalli, Sunitha
AU - Lee, Woo
PY - 2005
Y1 - 2005
N2 - In this work, a three phase solid catalyzed hydrogenation reaction of o-nitroanisole to produce o-anisidine in methanol was studied in a microreactor as a model pharmaceutical reaction. In the pharmaceutical industry, hydrogenation reactions constitute about 15-20% of the reactions and are generally carried out in batch reactors. Ineffective mass transfer and non-uniform temperature distribution in the batch reactor can have deleterious effects on reactor performance including the formation of undesired side products. These side products lead to product impurity necessitating costly separation processes. By using a microreactor for conducting such highly exothermic reactions, significantly improved heat and mass transfer can be achieved because of the high surface-to-volume ratio in these reactors. The product selectivity can also increase due to short reaction time because of the attainment of close to intrinsic kinetics in the microreactor, especially in reactions where products can further react catalytically to form side products. The main objective of this study is to compare the performance of the microreactor with a batch reactor using this model reaction. Experiments were conducted in a packed bed micro-reactor using Pd catalyst on different supports to determine the best support for the hydrogenation reaction. It was found that Pd supported on zeolite resulted in higher yield and selectivity compared to Pd on other supports. The effects of different processing conditions, e.g., reactor temperature, pressure, nitroanisole concentration in the feed on the conversion, yield and selectivity have been studied using the Pd supported on zeolite catalyst. Similar experiments were conducted in the batch reactor using the same catalyst for the comparison study.
AB - In this work, a three phase solid catalyzed hydrogenation reaction of o-nitroanisole to produce o-anisidine in methanol was studied in a microreactor as a model pharmaceutical reaction. In the pharmaceutical industry, hydrogenation reactions constitute about 15-20% of the reactions and are generally carried out in batch reactors. Ineffective mass transfer and non-uniform temperature distribution in the batch reactor can have deleterious effects on reactor performance including the formation of undesired side products. These side products lead to product impurity necessitating costly separation processes. By using a microreactor for conducting such highly exothermic reactions, significantly improved heat and mass transfer can be achieved because of the high surface-to-volume ratio in these reactors. The product selectivity can also increase due to short reaction time because of the attainment of close to intrinsic kinetics in the microreactor, especially in reactions where products can further react catalytically to form side products. The main objective of this study is to compare the performance of the microreactor with a batch reactor using this model reaction. Experiments were conducted in a packed bed micro-reactor using Pd catalyst on different supports to determine the best support for the hydrogenation reaction. It was found that Pd supported on zeolite resulted in higher yield and selectivity compared to Pd on other supports. The effects of different processing conditions, e.g., reactor temperature, pressure, nitroanisole concentration in the feed on the conversion, yield and selectivity have been studied using the Pd supported on zeolite catalyst. Similar experiments were conducted in the batch reactor using the same catalyst for the comparison study.
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M3 - Conference contribution
AN - SCOPUS:22444443075
SN - 0816909849
T3 - 2005 AIChE Spring National Meeting, Conference Proceedings
SP - 75
BT - 2005 AIChE Spring National Meeting, Conference Proceedings
T2 - 2005 AIChE Spring National Meeting
Y2 - 10 April 2005 through 14 April 2005
ER -