Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer

Yamin Yang, Ning Gao, Yue Hu, Chao Jia, Henry Du, Hongjun Wang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In recognition of the unique contribution of gold nanoparticles (Au NPs) and critical role of mitochondria in photodynamic reaction, mitochondria-targeting Au NPs are prepared and employed to photodynamic therapy (PDT) of breast cancer. Au NPs with positive surface charge are synthesized and modified with functional groups (triphenylphosphonium, TPP). The integration of positive surface charge with mitochondrion-targeting domain (i.e., TPP) onto Au NPs allow their selective accumulation in the mitochondria of breast cancer cells, leading to elevated reactive oxygen species (singlet oxygen 102, in particular) formation and significant improved destruction of breast cancer cells by 5-aminolevulinic acid (5-ALA)-assisted PDT under light irradaition. These findings provide guidance for the improved design of intracellular organelle- targeted therapeutic nanoparticles for PDT.

Original languageEnglish
Title of host publicationNSTI
Subtitle of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2015
EditorsMatthew Laudon, Bart Romanowicz
Pages98-101
Number of pages4
ISBN (Electronic)9781498747295
StatePublished - 2015
Event10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference - Washington, United States
Duration: 14 Jun 201517 Jun 2015

Publication series

NameNSTI: Advanced Materials - TechConnect Briefs 2015
Volume3

Conference

Conference10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference
Country/TerritoryUnited States
CityWashington
Period14/06/1517/06/15

Keywords

  • Gold nanoparticles
  • Mitochondria
  • Photodynamic therapy
  • Reactive oxygen species
  • Triphenylphosphonium

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