TY - GEN
T1 - Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer
AU - Yang, Yamin
AU - Gao, Ning
AU - Hu, Yue
AU - Jia, Chao
AU - Du, Henry
AU - Wang, Hongjun
N1 - Publisher Copyright:
Copyright 2015 by TechConnect. All rights reserved.
PY - 2015
Y1 - 2015
N2 - In recognition of the unique contribution of gold nanoparticles (Au NPs) and critical role of mitochondria in photodynamic reaction, mitochondria-targeting Au NPs are prepared and employed to photodynamic therapy (PDT) of breast cancer. Au NPs with positive surface charge are synthesized and modified with functional groups (triphenylphosphonium, TPP). The integration of positive surface charge with mitochondrion-targeting domain (i.e., TPP) onto Au NPs allow their selective accumulation in the mitochondria of breast cancer cells, leading to elevated reactive oxygen species (singlet oxygen 102, in particular) formation and significant improved destruction of breast cancer cells by 5-aminolevulinic acid (5-ALA)-assisted PDT under light irradaition. These findings provide guidance for the improved design of intracellular organelle- targeted therapeutic nanoparticles for PDT.
AB - In recognition of the unique contribution of gold nanoparticles (Au NPs) and critical role of mitochondria in photodynamic reaction, mitochondria-targeting Au NPs are prepared and employed to photodynamic therapy (PDT) of breast cancer. Au NPs with positive surface charge are synthesized and modified with functional groups (triphenylphosphonium, TPP). The integration of positive surface charge with mitochondrion-targeting domain (i.e., TPP) onto Au NPs allow their selective accumulation in the mitochondria of breast cancer cells, leading to elevated reactive oxygen species (singlet oxygen 102, in particular) formation and significant improved destruction of breast cancer cells by 5-aminolevulinic acid (5-ALA)-assisted PDT under light irradaition. These findings provide guidance for the improved design of intracellular organelle- targeted therapeutic nanoparticles for PDT.
KW - Gold nanoparticles
KW - Mitochondria
KW - Photodynamic therapy
KW - Reactive oxygen species
KW - Triphenylphosphonium
UR - http://www.scopus.com/inward/record.url?scp=84983381634&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983381634&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84983381634
T3 - NSTI: Advanced Materials - TechConnect Briefs 2015
SP - 98
EP - 101
BT - NSTI
A2 - Laudon, Matthew
A2 - Romanowicz, Bart
T2 - 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference
Y2 - 14 June 2015 through 17 June 2015
ER -