Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer

Yamin Yang; Ning Gao; Yue Hu; Chao Jia; Henry Du; Hongjun Wang

Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer

Yamin Yang
, Ning Gao
, Yue Hu
, Chao Jia
, Henry Du
, Hongjun Wang

Stevens Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In recognition of the unique contribution of gold nanoparticles (Au NPs) and critical role of mitochondria in photodynamic reaction, mitochondria-targeting Au NPs are prepared and employed to photodynamic therapy (PDT) of breast cancer. Au NPs with positive surface charge are synthesized and modified with functional groups (triphenylphosphonium, TPP). The integration of positive surface charge with mitochondrion-targeting domain (i.e., TPP) onto Au NPs allow their selective accumulation in the mitochondria of breast cancer cells, leading to elevated reactive oxygen species (singlet oxygen ¹0₂, in particular) formation and significant improved destruction of breast cancer cells by 5-aminolevulinic acid (5-ALA)-assisted PDT under light irradaition. These findings provide guidance for the improved design of intracellular organelle- targeted therapeutic nanoparticles for PDT.

Original language	English
Title of host publication	NSTI
Subtitle of host publication	Biotech, Biomaterials and Biomedical - TechConnect Briefs 2015
Editors	Matthew Laudon, Bart Romanowicz
Pages	98-101
Number of pages	4
ISBN (Electronic)	9781498747295
State	Published - 2015
Event	10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference - Washington, United States Duration: 14 Jun 2015 → 17 Jun 2015

Publication series

Name	NSTI: Advanced Materials - TechConnect Briefs 2015
Volume	3

Conference

Conference	10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference
Country/Territory	United States
City	Washington
Period	14/06/15 → 17/06/15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gold nanoparticles
Mitochondria
Photodynamic therapy
Reactive oxygen species
Triphenylphosphonium

Cite this

@inproceedings{1d38a5a0b61d4b08891e83527251e13b,

title = "Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer",

abstract = "In recognition of the unique contribution of gold nanoparticles (Au NPs) and critical role of mitochondria in photodynamic reaction, mitochondria-targeting Au NPs are prepared and employed to photodynamic therapy (PDT) of breast cancer. Au NPs with positive surface charge are synthesized and modified with functional groups (triphenylphosphonium, TPP). The integration of positive surface charge with mitochondrion-targeting domain (i.e., TPP) onto Au NPs allow their selective accumulation in the mitochondria of breast cancer cells, leading to elevated reactive oxygen species (singlet oxygen 102, in particular) formation and significant improved destruction of breast cancer cells by 5-aminolevulinic acid (5-ALA)-assisted PDT under light irradaition. These findings provide guidance for the improved design of intracellular organelle- targeted therapeutic nanoparticles for PDT.",

keywords = "Gold nanoparticles, Mitochondria, Photodynamic therapy, Reactive oxygen species, Triphenylphosphonium",

author = "Yamin Yang and Ning Gao and Yue Hu and Chao Jia and Henry Du and Hongjun Wang",

note = "Publisher Copyright: Copyright 2015 by TechConnect. All rights reserved.; 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference ; Conference date: 14-06-2015 Through 17-06-2015",

year = "2015",

language = "English",

series = "NSTI: Advanced Materials - TechConnect Briefs 2015",

pages = "98--101",

editor = "Matthew Laudon and Bart Romanowicz",

booktitle = "NSTI",

}

Yang, Y, Gao, N, Hu, Y, Jia, C, Du, H & Wang, H 2015, Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer. in M Laudon & B Romanowicz (eds), NSTI: Biotech, Biomaterials and Biomedical - TechConnect Briefs 2015. NSTI: Advanced Materials - TechConnect Briefs 2015, vol. 3, pp. 98-101, 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference, Washington, United States, 14/06/15.

Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer. / Yang, Yamin; Gao, Ning; Hu, Yue et al.
NSTI: Biotech, Biomaterials and Biomedical - TechConnect Briefs 2015. ed. / Matthew Laudon; Bart Romanowicz. 2015. p. 98-101 (NSTI: Advanced Materials - TechConnect Briefs 2015; Vol. 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer

AU - Yang, Yamin

AU - Gao, Ning

AU - Hu, Yue

AU - Jia, Chao

AU - Du, Henry

AU - Wang, Hongjun

PY - 2015

Y1 - 2015

N2 - In recognition of the unique contribution of gold nanoparticles (Au NPs) and critical role of mitochondria in photodynamic reaction, mitochondria-targeting Au NPs are prepared and employed to photodynamic therapy (PDT) of breast cancer. Au NPs with positive surface charge are synthesized and modified with functional groups (triphenylphosphonium, TPP). The integration of positive surface charge with mitochondrion-targeting domain (i.e., TPP) onto Au NPs allow their selective accumulation in the mitochondria of breast cancer cells, leading to elevated reactive oxygen species (singlet oxygen 102, in particular) formation and significant improved destruction of breast cancer cells by 5-aminolevulinic acid (5-ALA)-assisted PDT under light irradaition. These findings provide guidance for the improved design of intracellular organelle- targeted therapeutic nanoparticles for PDT.

AB - In recognition of the unique contribution of gold nanoparticles (Au NPs) and critical role of mitochondria in photodynamic reaction, mitochondria-targeting Au NPs are prepared and employed to photodynamic therapy (PDT) of breast cancer. Au NPs with positive surface charge are synthesized and modified with functional groups (triphenylphosphonium, TPP). The integration of positive surface charge with mitochondrion-targeting domain (i.e., TPP) onto Au NPs allow their selective accumulation in the mitochondria of breast cancer cells, leading to elevated reactive oxygen species (singlet oxygen 102, in particular) formation and significant improved destruction of breast cancer cells by 5-aminolevulinic acid (5-ALA)-assisted PDT under light irradaition. These findings provide guidance for the improved design of intracellular organelle- targeted therapeutic nanoparticles for PDT.

KW - Gold nanoparticles

KW - Mitochondria

KW - Photodynamic therapy

KW - Reactive oxygen species

KW - Triphenylphosphonium

UR - https://www.scopus.com/pages/publications/84983381634

UR - https://www.scopus.com/pages/publications/84983381634#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:84983381634

T3 - NSTI: Advanced Materials - TechConnect Briefs 2015

SP - 98

EP - 101

BT - NSTI

A2 - Laudon, Matthew

A2 - Romanowicz, Bart

T2 - 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference

Y2 - 14 June 2015 through 17 June 2015

ER -

Mitochondria-targeting gold nanoparticles for improved therapeutic efficacy of photodynamic therapy of breast cancer

Abstract

Publication series

Conference

UN SDGs

Keywords

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Cite this