TY - JOUR
T1 - More chemistry for less pollution
T2 - Applications for process development
AU - Bose, Ajay K.
AU - Manhas, Maghar S.
AU - Ganguly, Subhendu N.
AU - Sharma, Anju H.
AU - Banik, Bimal K.
PY - 2002
Y1 - 2002
N2 - Microwave-assisted rapid organic reactions constitute an emerging technology that could make industrially important organic syntheses more eco-friendly than conventional reactions. In our laboratory Microwave-Induced Organic Reaction Enhancement (MORE) chemistry techniques have been developed that are safe since all reactions are conducted in open systems to avoid any chance of explosions that have been observed in sealed systems. MORE chemistry can be conducted without an added solvent if one or more of the reactants is a liquid that absorbs microwaves efficiently. When it is necessary to add a dipolar solvent for transferring microwave energy to the reactants, it is adequate to add just enough solvent to form a slurry at room temperature. The growing concern about the effect of organic solvents and chemical wastes on the environment is attracting attention to non-traditional synthetic approaches that might 'reduce pollution at the source'. In this context MORE chemistry techniques are potentially valuable as they reduce the need for organic solvents and also increase 'atom economy' by improving product selectivity and chemical yield.
AB - Microwave-assisted rapid organic reactions constitute an emerging technology that could make industrially important organic syntheses more eco-friendly than conventional reactions. In our laboratory Microwave-Induced Organic Reaction Enhancement (MORE) chemistry techniques have been developed that are safe since all reactions are conducted in open systems to avoid any chance of explosions that have been observed in sealed systems. MORE chemistry can be conducted without an added solvent if one or more of the reactants is a liquid that absorbs microwaves efficiently. When it is necessary to add a dipolar solvent for transferring microwave energy to the reactants, it is adequate to add just enough solvent to form a slurry at room temperature. The growing concern about the effect of organic solvents and chemical wastes on the environment is attracting attention to non-traditional synthetic approaches that might 'reduce pollution at the source'. In this context MORE chemistry techniques are potentially valuable as they reduce the need for organic solvents and also increase 'atom economy' by improving product selectivity and chemical yield.
KW - Microwave enhanced synthesis
KW - Nitrene reaction
KW - Product selectivity
KW - Solventless reactions
KW - Synthesis in aqueous media
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U2 - 10.1055/s-2002-33344
DO - 10.1055/s-2002-33344
M3 - Article
AN - SCOPUS:0036367664
SN - 0039-7881
SP - 1578
EP - 1591
JO - Synthesis
JF - Synthesis
IS - 11
ER -