TY - JOUR
T1 - Multicontrast endomyocardial imaging by single-channel high-resolution cross-polarization optical coherence tomography
AU - Yao, Xinwen
AU - Gan, Yu
AU - Ling, Yuye
AU - Marboe, Charles C.
AU - Hendon, Christine P.
N1 - Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/4
Y1 - 2018/4
N2 - A single-channel high-resolution cross-polarization (CP) optical coherence tomography (OCT) system is presented for multicontrast imaging of human myocardium in one-shot measurement. The intensity and functional contrasts, including the ratio between the cross- and co-polarization channels as well as the cumulative retardation, are reconstructed from the CP-OCT readout. By comparing the CP-OCT results with histological analysis, it is shown that the system can successfully delineate microstructures in the myocardium and differentiate the fibrotic myocardium from normal or ablated myocardium based on the functional contrasts provided by the CP-OCT system. The feasibility of using A-line profiles from the 2 orthogonal polarization channels to identify fibrotic myocardium, normal myocardium and ablated lesion is also discussed.
AB - A single-channel high-resolution cross-polarization (CP) optical coherence tomography (OCT) system is presented for multicontrast imaging of human myocardium in one-shot measurement. The intensity and functional contrasts, including the ratio between the cross- and co-polarization channels as well as the cumulative retardation, are reconstructed from the CP-OCT readout. By comparing the CP-OCT results with histological analysis, it is shown that the system can successfully delineate microstructures in the myocardium and differentiate the fibrotic myocardium from normal or ablated myocardium based on the functional contrasts provided by the CP-OCT system. The feasibility of using A-line profiles from the 2 orthogonal polarization channels to identify fibrotic myocardium, normal myocardium and ablated lesion is also discussed.
KW - imaging systems
KW - medical and biological imaging
KW - myocardium imaging
KW - optical coherence tomography
KW - polarization-selective devices
KW - tissue characterization
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U2 - 10.1002/jbio.201700204
DO - 10.1002/jbio.201700204
M3 - Article
C2 - 29165902
AN - SCOPUS:85040234539
SN - 1864-063X
VL - 11
JO - Journal of Biophotonics
JF - Journal of Biophotonics
IS - 4
M1 - e201700204
ER -