TY - JOUR
T1 - Multiphysics of Prionlike Diseases
T2 - Progression and Atrophy
AU - Weickenmeier, Johannes
AU - Kuhl, Ellen
AU - Goriely, Alain
N1 - Publisher Copyright:
© 2018 authors.
PY - 2018/10/12
Y1 - 2018/10/12
N2 - Many neurodegenerative diseases are related to the propagation and accumulation of toxic proteins throughout the brain. The lesions created by aggregates of these toxic proteins further lead to cell death and accelerated tissue atrophy. A striking feature of some of these diseases is their characteristic pattern and evolution, leading to well-codified disease stages visible to neuropathology and associated with various cognitive deficits and pathologies. Here, we simulate the anisotropic propagation and accumulation of toxic proteins in full brain geometry. We show that the same model with different initial seeding zones reproduces the characteristic evolution of different prionlike diseases. We also recover the expected evolution of the total toxic protein load. Finally, we couple our transport model to a mechanical atrophy model to obtain the typical degeneration patterns found in neurodegenerative diseases.
AB - Many neurodegenerative diseases are related to the propagation and accumulation of toxic proteins throughout the brain. The lesions created by aggregates of these toxic proteins further lead to cell death and accelerated tissue atrophy. A striking feature of some of these diseases is their characteristic pattern and evolution, leading to well-codified disease stages visible to neuropathology and associated with various cognitive deficits and pathologies. Here, we simulate the anisotropic propagation and accumulation of toxic proteins in full brain geometry. We show that the same model with different initial seeding zones reproduces the characteristic evolution of different prionlike diseases. We also recover the expected evolution of the total toxic protein load. Finally, we couple our transport model to a mechanical atrophy model to obtain the typical degeneration patterns found in neurodegenerative diseases.
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U2 - 10.1103/PhysRevLett.121.158101
DO - 10.1103/PhysRevLett.121.158101
M3 - Article
C2 - 30362787
AN - SCOPUS:85054802448
SN - 0031-9007
VL - 121
JO - Physical Review Letters
JF - Physical Review Letters
IS - 15
M1 - 158101
ER -