Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography

Xinwen Yao, Yu Gan, Charles C. Marboe, Christine P. Hendon

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

We present an ultrahigh-resolution spectral domain optical coherence tomography (OCT) system in 800 nm with a low-noise supercontinuum source (SC) optimized for myocardial imaging. The system was demonstrated to have an axial resolution of 2.72 μm with a large imaging depth of 1.78 mm and a 6-dB falloff range of 0.89 mm. The lateral resolution (5.52 μm) was compromised to enhance the image penetration required for myocardial imaging. The noise of the SC source was analyzed extensively and an imaging protocol was proposed for SC-based OCT imaging with appreciable contrast. Three-dimensional datasets were acquired ex vivo on the endocardium side of tissue specimens from different chambers of fresh human and swine hearts. With the increased resolution and contrast, features such as elastic fibers, Purkinje fibers, and collagen fiber bundles were observed. The correlation between the structural information revealed in the OCT images and tissue pathology was discussed as well.

Original languageEnglish
Article number061006
JournalJournal of Biomedical Optics
Volume21
Issue number6
DOIs
StatePublished - 1 Jun 2016

Keywords

  • Optical coherence tomography
  • biomedical imaging
  • cardiology
  • myocardial imaging
  • supercontinuum source

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