TY - JOUR
T1 - Nanocrystal technology for drug formulation and delivery
AU - Chang, Tzu Lan
AU - Zhan, Honglei
AU - Liang, Danni
AU - Liang, Jun F.
N1 - Publisher Copyright:
© 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg.
PY - 2015/4/11
Y1 - 2015/4/11
N2 - With the development of modern technology like high throughput screening, combinatorial chemistry and computer aid drug design, the drug discovery process has been dramatically accelerated. However, new drug candidates often exhibit poor aqueous or even organic medium solubility. Additionally, many of them may have low dissolution velocity and low oral bioavailability. Nanocrystal formulation sheds new light on advanced drug development. Due to small (nano- or micro- meters) sizes, the increased surface-volume ratio leads to dramatically enhanced drug dissolution velocity and saturation solubility. The simplicity in preparation and the potential for various administration routes allow drug nanocrystals to be a novel drug delivery system for specific diseases (i.e. cancer). In addition to the comprehensive review of different technologies and methods in drug nanocrystal preparation, suspension, and stabilization, we will also compare nano- and micro-sized drug crystals in pharmaceutical applications and discuss current nanocrystal drugs on the market and their limitations.[Figure not available: see fulltext.]
AB - With the development of modern technology like high throughput screening, combinatorial chemistry and computer aid drug design, the drug discovery process has been dramatically accelerated. However, new drug candidates often exhibit poor aqueous or even organic medium solubility. Additionally, many of them may have low dissolution velocity and low oral bioavailability. Nanocrystal formulation sheds new light on advanced drug development. Due to small (nano- or micro- meters) sizes, the increased surface-volume ratio leads to dramatically enhanced drug dissolution velocity and saturation solubility. The simplicity in preparation and the potential for various administration routes allow drug nanocrystals to be a novel drug delivery system for specific diseases (i.e. cancer). In addition to the comprehensive review of different technologies and methods in drug nanocrystal preparation, suspension, and stabilization, we will also compare nano- and micro-sized drug crystals in pharmaceutical applications and discuss current nanocrystal drugs on the market and their limitations.[Figure not available: see fulltext.]
KW - bioavailability
KW - drug delivery
KW - drug nanocrystal
KW - formulation
KW - nanotechnology
KW - stabilizers
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U2 - 10.1007/s11705-015-1509-3
DO - 10.1007/s11705-015-1509-3
M3 - Review article
AN - SCOPUS:84937761952
SN - 2095-0179
VL - 9
JO - Frontiers of Chemical Science and Engineering
JF - Frontiers of Chemical Science and Engineering
IS - 1
ER -