TY - JOUR
T1 - Nanostructures for bypassing blood brain barrier
AU - Wang, Junping
AU - Valmikinathan, Chandra M.
AU - Yu, Xiaojun
PY - 2009/9
Y1 - 2009/9
N2 - The Blood Brain Barrier (BBB) represents a fundamental challenge towards development of therapy for disease in the brain such as brain tumor, Parkinson's disease and Alzheimer's disease. The passage across the BBB is vital to the success of a therapeutic platform and nanotechnology based systems provide great potential for solving the problem. This chapter discusses the structures and functions of the BBB, the transport mechanisms at the BBB, the strategies for crossing the BBB, and nanostructures for delivering drugs and imaging in the brain.
AB - The Blood Brain Barrier (BBB) represents a fundamental challenge towards development of therapy for disease in the brain such as brain tumor, Parkinson's disease and Alzheimer's disease. The passage across the BBB is vital to the success of a therapeutic platform and nanotechnology based systems provide great potential for solving the problem. This chapter discusses the structures and functions of the BBB, the transport mechanisms at the BBB, the strategies for crossing the BBB, and nanostructures for delivering drugs and imaging in the brain.
KW - Blood brain barrier
KW - Drug delivery
KW - Imaging
KW - Nanomaterials
KW - Nanoparticles
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U2 - 10.2174/157340709789054777
DO - 10.2174/157340709789054777
M3 - Review article
AN - SCOPUS:70449864545
SN - 1573-4072
VL - 5
SP - 195
EP - 205
JO - Current Bioactive Compounds
JF - Current Bioactive Compounds
IS - 3
ER -