Nanostructures for bypassing blood brain barrier

Junping Wang, Chandra M. Valmikinathan, Xiaojun Yu

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The Blood Brain Barrier (BBB) represents a fundamental challenge towards development of therapy for disease in the brain such as brain tumor, Parkinson's disease and Alzheimer's disease. The passage across the BBB is vital to the success of a therapeutic platform and nanotechnology based systems provide great potential for solving the problem. This chapter discusses the structures and functions of the BBB, the transport mechanisms at the BBB, the strategies for crossing the BBB, and nanostructures for delivering drugs and imaging in the brain.

Original languageEnglish
Pages (from-to)195-205
Number of pages11
JournalCurrent Bioactive Compounds
Volume5
Issue number3
DOIs
StatePublished - Sep 2009

Keywords

  • Blood brain barrier
  • Drug delivery
  • Imaging
  • Nanomaterials
  • Nanoparticles

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