TY - JOUR
T1 - Noncontact Elastic Wave Imaging Optical Coherence Elastography for Evaluating Changes in Corneal Elasticity Due to Crosslinking
AU - Singh, Manmohan
AU - Li, Jiasong
AU - Vantipalli, Srilatha
AU - Wang, Shang
AU - Han, Zhaolong
AU - Nair, Achuth
AU - Aglyamov, Salavat R.
AU - Twa, Michael D.
AU - Larin, Kirill V.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - The mechanical properties of tissues can provide valuable information about tissue integrity and health and can assist in detecting and monitoring the progression of diseases such as keratoconus. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess localized mechanical contrast in tissues with micrometer spatial resolution. In this paper, we present a noncontact method of OCE to evaluate the changes in the mechanical properties of the cornea after UV-induced collagen crosslinking. A focused air-pulse induced a low-amplitude (micrometer scale) elastic wave, which then propagated radially and was imaged in three dimensions by a phase-stabilized swept-source optical coherence tomography system. The elastic wave velocity was translated to Young's modulus in agar phantoms of various concentrations. Additionally, the speed of the elastic wave significantly changed in porcine cornea before and after UV-induced corneal collagen crosslinking (CXL). Moreover, different layers of the cornea, such as the anterior stroma, posterior stroma, and inner region, could be discerned from the phase velocities of the elastic wave. Therefore, because of noncontact excitation and imaging, this method may be useful for in vivo detection of ocular diseases such as keratoconus and evaluation of therapeutic interventions such as CXL.
AB - The mechanical properties of tissues can provide valuable information about tissue integrity and health and can assist in detecting and monitoring the progression of diseases such as keratoconus. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess localized mechanical contrast in tissues with micrometer spatial resolution. In this paper, we present a noncontact method of OCE to evaluate the changes in the mechanical properties of the cornea after UV-induced collagen crosslinking. A focused air-pulse induced a low-amplitude (micrometer scale) elastic wave, which then propagated radially and was imaged in three dimensions by a phase-stabilized swept-source optical coherence tomography system. The elastic wave velocity was translated to Young's modulus in agar phantoms of various concentrations. Additionally, the speed of the elastic wave significantly changed in porcine cornea before and after UV-induced corneal collagen crosslinking (CXL). Moreover, different layers of the cornea, such as the anterior stroma, posterior stroma, and inner region, could be discerned from the phase velocities of the elastic wave. Therefore, because of noncontact excitation and imaging, this method may be useful for in vivo detection of ocular diseases such as keratoconus and evaluation of therapeutic interventions such as CXL.
KW - Biomechanical properties
KW - cornea
KW - elasticity
KW - optical coherence elastography
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U2 - 10.1109/JSTQE.2015.2510293
DO - 10.1109/JSTQE.2015.2510293
M3 - Article
AN - SCOPUS:84963943827
SN - 1077-260X
VL - 22
SP - 266
EP - 276
JO - IEEE Journal of Selected Topics in Quantum Electronics
JF - IEEE Journal of Selected Topics in Quantum Electronics
IS - 3
M1 - 7360127
ER -