TY - JOUR
T1 - Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system
AU - Wang, Shang
AU - Li, Jiasong
AU - Manapuram, Ravi Kiran
AU - Menodiado, Floredes M.
AU - Ingram, Davis R.
AU - Twa, Michael D.
AU - Lazar, Alexander J.
AU - Lev, Dina C.
AU - Pollock, Raphael E.
AU - Larin, Kirill V.
PY - 2012/12/15
Y1 - 2012/12/15
N2 - We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young's modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues.
AB - We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young's modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues.
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U2 - 10.1364/OL.37.005184
DO - 10.1364/OL.37.005184
M3 - Article
C2 - 23258046
AN - SCOPUS:84871271797
SN - 0146-9592
VL - 37
SP - 5184
EP - 5186
JO - Optics Letters
JF - Optics Letters
IS - 24
ER -