Noninvasive 3D elasticity mapping using phase-stabilized optical coherence elastography

Manmohan Singh, Jiasong Li, Shang Wang, Michael Twa, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We demonstrate a novel method for noninvasive elasticity mapping in three dimensions using phase stabilized swept source optical coherence elastography (PhS-SSOCE). By calculating the velocity in all radial directions from the origin of the induced shear wave, a volumetric elasticity map of the sample was generated. Due to the submicrometer spatial sensitivity of PhS-SSOCE, the loading force and the induced deformation amplitude can be minimal, thus preserving the structure and function of delicate tissues such as the cornea and sclera of the eye. Tissue mimicking agar phantoms were utilized for proof of concept testing and the results show that this method can noninvasively provide a three dimensional estimation of sample elasticity.

Original languageEnglish
Title of host publicationOptical Elastography and Tissue Biomechanics II
EditorsKirill V. Larin, David D. Sampson
ISBN (Electronic)9781628414172
DOIs
StatePublished - 2015
EventOptical Elastography and Tissue Biomechanics II - San Francisco, United States
Duration: 7 Feb 20158 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9327
ISSN (Print)1605-7422

Conference

ConferenceOptical Elastography and Tissue Biomechanics II
Country/TerritoryUnited States
CitySan Francisco
Period7/02/158/02/15

Keywords

  • Elasticity
  • Optical coherence elastography
  • Shear wave
  • Three dimensional

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