Novel synthesis of physovenine and physostigmine analogs

C. H. Wang, S. Alluri, G. Nikogosyan, C. Decarlo, C. Monteiro, G. Mabagos, H. H. Feng, A. R. White, M. Bartolini, V. Andrisano, L. K. Zhang, A. K. Ganguly

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.

Original languageEnglish
Pages (from-to)3046-3049
Number of pages4
JournalTetrahedron Letters
Volume57
Issue number27-28
DOIs
StatePublished - 2016

Keywords

  • AChE inhibitors
  • Physovenine and physostigmine analogs
  • Radical reactions

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