Novel synthesis of physovenine and physostigmine analogs

C. H. Wang; S. Alluri; G. Nikogosyan; C. Decarlo; C. Monteiro; G. Mabagos; H. H. Feng; A. R. White; M. Bartolini; V. Andrisano; L. K. Zhang; A. K. Ganguly

doi:10.1016/j.tetlet.2016.06.005

Novel synthesis of physovenine and physostigmine analogs

C. H. Wang, S. Alluri, G. Nikogosyan, C. Decarlo, C. Monteiro, G. Mabagos, H. H. Feng, A. R. White, M. Bartolini, V. Andrisano, L. K. Zhang, A. K. Ganguly

Department of Chemistry and Chemical Biology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.

Original language	English
Pages (from-to)	3046-3049
Number of pages	4
Journal	Tetrahedron Letters
Volume	57
Issue number	27-28
DOIs	https://doi.org/10.1016/j.tetlet.2016.06.005
State	Published - 2016

Keywords

AChE inhibitors
Physovenine and physostigmine analogs
Radical reactions

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10.1016/j.tetlet.2016.06.005

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title = "Novel synthesis of physovenine and physostigmine analogs",

abstract = "This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.",

keywords = "AChE inhibitors, Physovenine and physostigmine analogs, Radical reactions",

author = "Wang, \{C. H.\} and S. Alluri and G. Nikogosyan and C. Decarlo and C. Monteiro and G. Mabagos and Feng, \{H. H.\} and White, \{A. R.\} and M. Bartolini and V. Andrisano and Zhang, \{L. K.\} and Ganguly, \{A. K.\}",

year = "2016",

doi = "10.1016/j.tetlet.2016.06.005",

language = "English",

volume = "57",

pages = "3046--3049",

number = "27-28",

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TY - JOUR

T1 - Novel synthesis of physovenine and physostigmine analogs

AU - Wang, C. H.

AU - Alluri, S.

AU - Nikogosyan, G.

AU - Decarlo, C.

AU - Monteiro, C.

AU - Mabagos, G.

AU - Feng, H. H.

AU - White, A. R.

AU - Bartolini, M.

AU - Andrisano, V.

AU - Zhang, L. K.

AU - Ganguly, A. K.

PY - 2016

Y1 - 2016

N2 - This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.

AB - This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.

KW - AChE inhibitors

KW - Physovenine and physostigmine analogs

KW - Radical reactions

UR - https://www.scopus.com/pages/publications/84974602926

UR - https://www.scopus.com/inward/citedby.url?scp=84974602926&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2016.06.005

DO - 10.1016/j.tetlet.2016.06.005

M3 - Article

AN - SCOPUS:84974602926

SN - 0040-4039

VL - 57

SP - 3046

EP - 3049

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 27-28

ER -

Novel synthesis of physovenine and physostigmine analogs

Abstract

Keywords

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