Novel synthesis of physovenine and physostigmine analogs

C. H. Wang; S. Alluri; G. Nikogosyan; C. Decarlo; C. Monteiro; G. Mabagos; H. H. Feng; A. R. White; M. Bartolini; V. Andrisano; L. K. Zhang; A. K. Ganguly

doi:10.1016/j.tetlet.2016.06.005

Novel synthesis of physovenine and physostigmine analogs

C. H. Wang
, S. Alluri
, G. Nikogosyan
, C. Decarlo
, C. Monteiro
, G. Mabagos
, H. H. Feng
, A. R. White
, M. Bartolini
, V. Andrisano
, L. K. Zhang
, A. K. Ganguly

Department of Chemistry and Chemical Biology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.

Original language	English
Pages (from-to)	3046-3049
Number of pages	4
Journal	Tetrahedron Letters
Volume	57
Issue number	27-28
DOIs	https://doi.org/10.1016/j.tetlet.2016.06.005
State	Published - 2016

Keywords

AChE inhibitors
Physovenine and physostigmine analogs
Radical reactions

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10.1016/j.tetlet.2016.06.005

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title = "Novel synthesis of physovenine and physostigmine analogs",

abstract = "This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.",

keywords = "AChE inhibitors, Physovenine and physostigmine analogs, Radical reactions",

author = "Wang, \{C. H.\} and S. Alluri and G. Nikogosyan and C. Decarlo and C. Monteiro and G. Mabagos and Feng, \{H. H.\} and White, \{A. R.\} and M. Bartolini and V. Andrisano and Zhang, \{L. K.\} and Ganguly, \{A. K.\}",

year = "2016",

doi = "10.1016/j.tetlet.2016.06.005",

language = "English",

volume = "57",

pages = "3046--3049",

number = "27-28",

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TY - JOUR

T1 - Novel synthesis of physovenine and physostigmine analogs

AU - Wang, C. H.

AU - Alluri, S.

AU - Nikogosyan, G.

AU - Decarlo, C.

AU - Monteiro, C.

AU - Mabagos, G.

AU - Feng, H. H.

AU - White, A. R.

AU - Bartolini, M.

AU - Andrisano, V.

AU - Zhang, L. K.

AU - Ganguly, A. K.

PY - 2016

Y1 - 2016

N2 - This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.

AB - This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) from human serum.

KW - AChE inhibitors

KW - Physovenine and physostigmine analogs

KW - Radical reactions

UR - https://www.scopus.com/pages/publications/84974602926

UR - https://www.scopus.com/pages/publications/84974602926#tab=citedBy

U2 - 10.1016/j.tetlet.2016.06.005

DO - 10.1016/j.tetlet.2016.06.005

M3 - Article

AN - SCOPUS:84974602926

SN - 0040-4039

VL - 57

SP - 3046

EP - 3049

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 27-28

ER -

Novel synthesis of physovenine and physostigmine analogs

Abstract

Keywords

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