Optical sensing of macromolecules and microparticles distribution in tissues

K. V. Larin, S. Wang, P. Ruchhoeft, R. Willson, J. D. Morrisett, M. G. Ghosn

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.

Original languageEnglish
Title of host publicationIEEE SENSORS 2012 - Proceedings
DOIs
StatePublished - 2012
Event11th IEEE SENSORS 2012 Conference - Taipei, Taiwan, Province of China
Duration: 28 Oct 201231 Oct 2012

Publication series

NameProceedings of IEEE Sensors

Conference

Conference11th IEEE SENSORS 2012 Conference
Country/TerritoryTaiwan, Province of China
CityTaipei
Period28/10/1231/10/12

Fingerprint

Dive into the research topics of 'Optical sensing of macromolecules and microparticles distribution in tissues'. Together they form a unique fingerprint.

Cite this