TY - GEN
T1 - Optical sensing of macromolecules and microparticles distribution in tissues
AU - Larin, K. V.
AU - Wang, S.
AU - Ruchhoeft, P.
AU - Willson, R.
AU - Morrisett, J. D.
AU - Ghosn, M. G.
PY - 2012
Y1 - 2012
N2 - This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.
AB - This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.
UR - http://www.scopus.com/inward/record.url?scp=84873970918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873970918&partnerID=8YFLogxK
U2 - 10.1109/ICSENS.2012.6411079
DO - 10.1109/ICSENS.2012.6411079
M3 - Conference contribution
AN - SCOPUS:84873970918
SN - 9781457717659
T3 - Proceedings of IEEE Sensors
BT - IEEE SENSORS 2012 - Proceedings
T2 - 11th IEEE SENSORS 2012 Conference
Y2 - 28 October 2012 through 31 October 2012
ER -