Optical sensing of macromolecules and microparticles distribution in tissues

K. V. Larin; S. Wang; P. Ruchhoeft; R. Willson; J. D. Morrisett; M. G. Ghosn

doi:10.1109/ICSENS.2012.6411079

Optical sensing of macromolecules and microparticles distribution in tissues

K. V. Larin
, S. Wang
, P. Ruchhoeft
, R. Willson
, J. D. Morrisett
, M. G. Ghosn

Department of Biomedical Engineering

University of Houston

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.

Original language	English
Title of host publication	IEEE SENSORS 2012 - Proceedings
DOIs	https://doi.org/10.1109/ICSENS.2012.6411079
State	Published - 2012
Event	11th IEEE SENSORS 2012 Conference - Taipei, Taiwan, Province of China Duration: 28 Oct 2012 → 31 Oct 2012

Publication series

Name	Proceedings of IEEE Sensors

Conference

Conference	11th IEEE SENSORS 2012 Conference
Country/Territory	Taiwan, Province of China
City	Taipei
Period	28/10/12 → 31/10/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1109/ICSENS.2012.6411079

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title = "Optical sensing of macromolecules and microparticles distribution in tissues",

abstract = "This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.",

author = "Larin, \{K. V.\} and S. Wang and P. Ruchhoeft and R. Willson and Morrisett, \{J. D.\} and Ghosn, \{M. G.\}",

year = "2012",

doi = "10.1109/ICSENS.2012.6411079",

language = "English",

isbn = "9781457717659",

series = "Proceedings of IEEE Sensors",

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note = "11th IEEE SENSORS 2012 Conference ; Conference date: 28-10-2012 Through 31-10-2012",

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T1 - Optical sensing of macromolecules and microparticles distribution in tissues

AU - Larin, K. V.

AU - Wang, S.

AU - Ruchhoeft, P.

AU - Willson, R.

AU - Morrisett, J. D.

AU - Ghosn, M. G.

PY - 2012

Y1 - 2012

N2 - This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.

AB - This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.

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U2 - 10.1109/ICSENS.2012.6411079

DO - 10.1109/ICSENS.2012.6411079

M3 - Conference contribution

AN - SCOPUS:84873970918

SN - 9781457717659

T3 - Proceedings of IEEE Sensors

BT - IEEE SENSORS 2012 - Proceedings

T2 - 11th IEEE SENSORS 2012 Conference

Y2 - 28 October 2012 through 31 October 2012

ER -

Optical sensing of macromolecules and microparticles distribution in tissues

Abstract

Publication series

Conference

UN SDGs

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