Optimizing the protocol for retinal vascular permeability mapping from fluorescein video angiography data

Elif Kayaalp-Nalbant, Laasya Annepureddy, Shaoxian Hu, Wenqiang Liu, Fangyao Tang, Zihan Sun, Carol Y. Cheung, William F. Mieler, Jennifer J. Kang-Mieler, Kenneth M. Tichauer

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

An intact blood-retinal barrier is critical to maintaining the function of the retina. Many diseases of the eye have been directly associated with impairment in vascular permeability, and methods to measure vascular permeability could offer a window into early detection of disease; however, there exist no direct measures of vascular permeability that have be translated to the clinic. This work details a complete clinical workflow to quantify vascular permeability and volumetric blood flow from fluorescein videoangiography data, with validation through realistic simulations. For optimizing the protocol, this study carried on frame rate of fluorescein videoangiography to generate a high-resolution image while minimizing the error.

Original languageEnglish
Title of host publicationOphthalmic Technologies XXXII
EditorsDaniel X. Hammer, Karen M. Joos, Daniel V. Palanker
ISBN (Electronic)9781510647534
DOIs
StatePublished - 2022
EventOphthalmic Technologies XXXII 2022 - Virtual, Online
Duration: 20 Feb 202224 Feb 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11941
ISSN (Print)1605-7422

Conference

ConferenceOphthalmic Technologies XXXII 2022
CityVirtual, Online
Period20/02/2224/02/22

Keywords

  • Retinopathy
  • fluorescein videoangiography
  • mathematical model

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