Abstract
Organ printing encompasses bioadditive, digitally controlled manufacturing processes for layered, patterned deposition of complex 3D cell-bearing biological structures. This chapter discusses printing techniques that have evolved to process high-density biopolymer cell suspensions. A review of state-of-art technologies points to a need to address the competing requirements of manufacturing scalability with large-volume patterning for clinical translation with biological exigencies to present cells with an in vivo microscale niche. To instruct process design and development, computational models of printed micro-organ testbeds, in tandem with an integrated strategy of materials processing, process modeling, and metrology for benchmarking functional tissue, will be critical.
Original language | English |
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Title of host publication | 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine |
Pages | 333-347 |
Number of pages | 15 |
ISBN (Electronic) | 9780128006641 |
DOIs | |
State | Published - 27 Jan 2015 |
Keywords
- Bioadditive manufacturing
- Biofabrication
- Computational modeling
- Micro-organ
- Microextrusion-based printing
- Organ printing
- Regenerative medicine
- Tissue engineering
- Tissue printing
- Tissue-on-a-chip