Pathogen transfer through environment-host contact: An agent-based queueing theoretic framework

Shi Chen, Suzanne Lenhart, Judy D. Day, Chihoon Lee, Michael Dulin, Cristina Lanzas

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Queueing theory studies the properties of waiting queues and has been applied to investigate direct hostto- host transmitted disease dynamics, but its potential in modelling environmentally transmitted pathogens has not been fully explored. In this study, we provide a flexible and customizable queueing theory modelling framework with three major subroutines to study the in-hospital contact processes between environments and hosts and potential nosocomial pathogen transfer, where environments are servers and hosts are customers. Two types of servers with different parameters but the same utilization are investigated. We consider various forms of transfer functions that map contact duration to the amount of pathogen transfer based on existing literature. We propose a case study of simulated in-hospital contact processes and apply stochastic queues to analyse the amount of pathogen transfer under different transfer functions, and assume that pathogen amount decreases during the inter-arrival time. Different host behaviour (feedback and non-feedback) as well as initial pathogen distribution (whether in environment and/or in hosts) are also considered and simulated. We assess pathogen transfer and circulation under these various conditions and highlight the importance of the nonlinear interactions among contact processes, transfer functions and pathogen demography during the contact process. Our modelling framework can be readily extended to more complicated queueing networks to simulate more realistic situations by adjusting parameters such as the number and type of servers and customers, and adding extra subroutines.

Original languageEnglish
Pages (from-to)409-425
Number of pages17
JournalMathematical Medicine and Biology
Volume35
Issue number3
DOIs
StatePublished - 11 Sep 2018

Keywords

  • Agent-based model
  • Environment-host contact
  • Health care contact process
  • Model framework
  • Pathogen transfer and decay
  • Queueing theory

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