Pd/Cu-catalyzed C-H arylation of 1,3,4-thiadiazoles with (hetero)aryl iodides, bromides, and triflates

Dipak D. Vachhani, Abhishek Sharma, Erik Van Der Eycken

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The direct C-H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C-H arylation-Suzuki coupling sequence.

Original languageEnglish
Pages (from-to)8768-8774
Number of pages7
JournalJournal of Organic Chemistry
Volume77
Issue number19
DOIs
StatePublished - 5 Oct 2012

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