TY - JOUR
T1 - Pd/Cu-catalyzed C-H arylation of 1,3,4-thiadiazoles with (hetero)aryl iodides, bromides, and triflates
AU - Vachhani, Dipak D.
AU - Sharma, Abhishek
AU - Van Der Eycken, Erik
PY - 2012/10/5
Y1 - 2012/10/5
N2 - The direct C-H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C-H arylation-Suzuki coupling sequence.
AB - The direct C-H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C-H arylation-Suzuki coupling sequence.
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U2 - 10.1021/jo301401q
DO - 10.1021/jo301401q
M3 - Article
C2 - 22957511
AN - SCOPUS:84867374032
SN - 0022-3263
VL - 77
SP - 8768
EP - 8774
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 19
ER -