PEG-based microgels to modify biomaterials surfaces

Yong Wu, Qichen Wang, Matthew Libera

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Summary Microgels are hydrogel particles ∼0.1-10 microns in size which have been increasingly explored for biomaterials applications. They can be designed to sequester drugs based on both hydrophobic and electrostatic interactions, and different strategies exist to trigger drug release from them. Microgels based on poly(ethylene glycol) are particularly attractive because of their intrinsic antifouling properties, the flexibility they bring to microgel design and synthesis, and the regulatory precedents set by PEG's use in a number of FDA-approved applications. This paper briefly reviews progress in the field of PEG-based microgels. We give examples illustrating their electrostatic deposition onto biomaterial surfaces and their ability to sequester antimicrobials for applications involving biomaterials-associated infection.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalMacromolecular Symposia
Volume329
Issue number1
DOIs
StatePublished - Jul 2013

Keywords

  • biomaterials
  • drug delivery
  • infection
  • microgels
  • poly(ethylene glycol)

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