Peptide oligomers from ultra-short peptides using sortase

Natalya Voloshchuk, Long Chen, Qiang Li, Jun F. Liang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Sortase A catalyzed ligation of ultra-short peptides leads to inter/intra-molecular transpeptidation to form either linear or cyclic oligomers dependent upon the peptide length. Cyclic peptides were the main products for peptides with more than 15aa. However, for ultra-short (<15aa) peptides, cyclic oligomers became predominant in prolonged reactions. Peptides with 1–3 aminoglycines were equally active but peptide oligomers from peptide containing more than one aminoglycine were prone to hydrolysis.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalBiochemistry and Biophysics Reports
Volume10
DOIs
StatePublished - 1 Jul 2017

Keywords

  • Cyclic peptide
  • Ligation
  • Peptide oligomer
  • Sortase
  • Ultra-short peptide

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