TY - JOUR
T1 - Peripheral nerve regeneration strategies
T2 - Electrically stimulating polymer based nerve growth conduits
AU - Anderson, Matthew
AU - Shelke, Namdev B.
AU - Manoukian, Ohan S.
AU - Yu, Xiaojun
AU - McCullough, Louise D.
AU - Kumbar, Sangamesh G.
N1 - Publisher Copyright:
© 2015 Begell House, Inc.
PY - 2015
Y1 - 2015
N2 - Treatment of large peripheral nerve damages ranges from the use of an autologous nerve graft to a synthetic nerve growth conduit. Biological grafts, in spite of many merits, show several limitations in terms of availability and donor site morbidity, and outcomes are suboptimal due to fascicle mismatch, scarring, and fibrosis. Tissue engineered nerve graft substitutes utilize polymeric conduits in conjunction with cues both chemical and physical, cells alone and or in combination. The chemical and physical cues delivered through polymeric conduits play an important role and drive tissue regeneration. Electrical stimulation (ES) has been applied toward the repair and regeneration of various tissues such as muscle, tendon, nerve, and articular tissue both in laboratory and clinical settings. The underlying mechanisms that regulate cellular activities such as cell adhesion, proliferation, cell migration, protein production, and tissue regeneration following ES is not fully understood. Polymeric constructs that can carry the electrical stimulation along the length of the scaffold have been developed and characterized for possible nerve regeneration applications. We discuss the use of electrically conductive polymers and associated cell interaction, biocompatibility, tissue regeneration, and recent basic research for nerve regeneration. In conclusion, a multifunctional combinatorial device comprised of biomaterial, structural, functional, cellular, and molecular aspects may be the best way forward for effective peripheral nerve regeneration.
AB - Treatment of large peripheral nerve damages ranges from the use of an autologous nerve graft to a synthetic nerve growth conduit. Biological grafts, in spite of many merits, show several limitations in terms of availability and donor site morbidity, and outcomes are suboptimal due to fascicle mismatch, scarring, and fibrosis. Tissue engineered nerve graft substitutes utilize polymeric conduits in conjunction with cues both chemical and physical, cells alone and or in combination. The chemical and physical cues delivered through polymeric conduits play an important role and drive tissue regeneration. Electrical stimulation (ES) has been applied toward the repair and regeneration of various tissues such as muscle, tendon, nerve, and articular tissue both in laboratory and clinical settings. The underlying mechanisms that regulate cellular activities such as cell adhesion, proliferation, cell migration, protein production, and tissue regeneration following ES is not fully understood. Polymeric constructs that can carry the electrical stimulation along the length of the scaffold have been developed and characterized for possible nerve regeneration applications. We discuss the use of electrically conductive polymers and associated cell interaction, biocompatibility, tissue regeneration, and recent basic research for nerve regeneration. In conclusion, a multifunctional combinatorial device comprised of biomaterial, structural, functional, cellular, and molecular aspects may be the best way forward for effective peripheral nerve regeneration.
KW - Electrical stimulation
KW - Electrically conducting polymers
KW - Nerve growth conduit
KW - Peripheral nerve regeneration
KW - Tissue engineering
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UR - http://www.scopus.com/inward/citedby.url?scp=84960380430&partnerID=8YFLogxK
U2 - 10.1615/critrevbiomedeng.2015014015
DO - 10.1615/critrevbiomedeng.2015014015
M3 - Article
C2 - 27278739
AN - SCOPUS:84960380430
SN - 0278-940X
VL - 43
SP - 131
EP - 149
JO - Critical Reviews in Biomedical Engineering
JF - Critical Reviews in Biomedical Engineering
IS - 2-3
ER -