Personalized early stage alzheimer's disease detection: A case study of president reagan's speeches

Ning Wang, Fan Luo, Vishal Peddagangireddy, K. P. Subbalakshmi, R. Chandramouli

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

Alzheimer's disease (AD)-related global healthcare cost is estimated to be $1 trillion by 2050. Currently, there is no cure for this disease; however, clinical studies show that early diagnosis and intervention helps to extend the quality of life and inform technologies for personalized mental healthcare. Clinical research indicates that the onset and progression of Alzheimer's disease lead to dementia and other mental health issues. As a result, the language capabilities of patient start to decline. In this paper, we show that machine learningbased unsupervised clustering of and anomaly detection with linguistic biomarkers are promising approaches for intuitive visualization and personalized early stage detection of Alzheimer's disease. We demonstrate this approach on 10 year's (1980 to 1989) of President Ronald Reagan's speech data set. Key linguistic biomarkers that indicate early-stage AD are identified. Experimental results show that Reagan had early onset of Alzheimer's sometime between 1983 and 1987. This finding is corroborated by prior work that analyzed his interviews using a statistical technique.

Original languageEnglish
Title of host publicationBioNLP 2020 - 19th SIGBioMed Workshop on Biomedical Language Processing, Proceedings of the Workshop
Pages133-139
Number of pages7
ISBN (Electronic)9781952148095
StatePublished - 2020
Event19th SIGBioMed Workshop on Biomedical Language Processing, BioNLP 2020 at the 58th Annual Meeting of the Association for Computational Linguistics, ACL 2020 - Virtual, Online, United States
Duration: 9 Jul 2020 → …

Publication series

NameProceedings of the Annual Meeting of the Association for Computational Linguistics
ISSN (Print)0736-587X

Conference

Conference19th SIGBioMed Workshop on Biomedical Language Processing, BioNLP 2020 at the 58th Annual Meeting of the Association for Computational Linguistics, ACL 2020
Country/TerritoryUnited States
CityVirtual, Online
Period9/07/20 → …

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