Positive end expiratory pressure: Effects on lung mechanics of premature lambs

T. H. Shaffer; P. A. Koen; G. D. Moskowitz; J. D. Ferguson; M. Delivoria-Papadopoulos

doi:10.1159/000241098

Positive end expiratory pressure: Effects on lung mechanics of premature lambs

T. H. Shaffer, P. A. Koen, G. D. Moskowitz, J. D. Ferguson, M. Delivoria-Papadopoulos

School of Business

University of Pennsylvania

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Pulmonary mechanics were determined at 0, 3, 6, and 10 cm H₂O positive end expiratory pressure (PEEP) in premature lambs at a mean gestational age of 134 days. Functional residual capacity increased (p <0.005) by 7% (1.6 ml/kg) per cm H₂O PEEP. Dynamic lung compliance and specific compliance significantly decreased by 10% (0.11 ml/cm H₂O/kg) and 9% (0.0051 l/cm H₂O) per cm H₂O PEEP, respectively, for PEEP above 3 cm H₂O level. Inspiratory lung resistance increased significantly (p <0.05) only between 0 and 6 cm H₂O PEEP while expiratory lung resistance increased (p <0.05) between 0 cm H₂O PEEP and all higher levels. The data suggest that PEEP in excess of 3 cm H₂O produces undesirable effects on lung mechanics in premature lambs. These results may be important in predicting contraindications and potential complications of positive pressure breathing in the newborn.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Unknown Journal
Volume	34
Issue number	1-2
DOIs	https://doi.org/10.1159/000241098
State	Published - 1978

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title = "Positive end expiratory pressure: Effects on lung mechanics of premature lambs",

abstract = "Pulmonary mechanics were determined at 0, 3, 6, and 10 cm H2O positive end expiratory pressure (PEEP) in premature lambs at a mean gestational age of 134 days. Functional residual capacity increased (p <0.005) by 7% (1.6 ml/kg) per cm H2O PEEP. Dynamic lung compliance and specific compliance significantly decreased by 10% (0.11 ml/cm H2O/kg) and 9% (0.0051 l/cm H2O) per cm H2O PEEP, respectively, for PEEP above 3 cm H2O level. Inspiratory lung resistance increased significantly (p <0.05) only between 0 and 6 cm H2O PEEP while expiratory lung resistance increased (p <0.05) between 0 cm H2O PEEP and all higher levels. The data suggest that PEEP in excess of 3 cm H2O produces undesirable effects on lung mechanics in premature lambs. These results may be important in predicting contraindications and potential complications of positive pressure breathing in the newborn.",

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T2 - Effects on lung mechanics of premature lambs

AU - Shaffer, T. H.

AU - Koen, P. A.

AU - Moskowitz, G. D.

AU - Ferguson, J. D.

AU - Delivoria-Papadopoulos, M.

PY - 1978

Y1 - 1978

N2 - Pulmonary mechanics were determined at 0, 3, 6, and 10 cm H2O positive end expiratory pressure (PEEP) in premature lambs at a mean gestational age of 134 days. Functional residual capacity increased (p <0.005) by 7% (1.6 ml/kg) per cm H2O PEEP. Dynamic lung compliance and specific compliance significantly decreased by 10% (0.11 ml/cm H2O/kg) and 9% (0.0051 l/cm H2O) per cm H2O PEEP, respectively, for PEEP above 3 cm H2O level. Inspiratory lung resistance increased significantly (p <0.05) only between 0 and 6 cm H2O PEEP while expiratory lung resistance increased (p <0.05) between 0 cm H2O PEEP and all higher levels. The data suggest that PEEP in excess of 3 cm H2O produces undesirable effects on lung mechanics in premature lambs. These results may be important in predicting contraindications and potential complications of positive pressure breathing in the newborn.

AB - Pulmonary mechanics were determined at 0, 3, 6, and 10 cm H2O positive end expiratory pressure (PEEP) in premature lambs at a mean gestational age of 134 days. Functional residual capacity increased (p <0.005) by 7% (1.6 ml/kg) per cm H2O PEEP. Dynamic lung compliance and specific compliance significantly decreased by 10% (0.11 ml/cm H2O/kg) and 9% (0.0051 l/cm H2O) per cm H2O PEEP, respectively, for PEEP above 3 cm H2O level. Inspiratory lung resistance increased significantly (p <0.05) only between 0 and 6 cm H2O PEEP while expiratory lung resistance increased (p <0.05) between 0 cm H2O PEEP and all higher levels. The data suggest that PEEP in excess of 3 cm H2O produces undesirable effects on lung mechanics in premature lambs. These results may be important in predicting contraindications and potential complications of positive pressure breathing in the newborn.

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Positive end expiratory pressure: Effects on lung mechanics of premature lambs

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