TY - JOUR
T1 - Predicted oxygenation efficacy of a thoracic artificial lung
AU - Perlman, Carrie E.
AU - Mockros, Lyle F.
PY - 2012/5
Y1 - 2012/5
N2 - A thoracic artificial lung (TAL) provides respiratory support for lung disease. How well a TAL improves blood oxygenation for a specific pathology depends on how the TAL is attached to the pulmonary circulation: in series with the natural lungs (NLs), in parallel, or in a hybrid series/parallel combination. A computational model, including hemodynamic and O2 and CO2 exchange components, predicts TAL effects on blood flow rates and gas transport in pulmonary disease states modeled by elevated pulmonary vascular resistance (PVR) or reduced oxygen diffusivity in the NLs. In most cases, parallel and series TAL attachment provide comparable, maximal oxygenation. Series, with passage of total cardiac output (CO) through the NLs, is preferred for its filtration of emboli. Hybrid TAL attachment is more complicated, requiring a third graft, yet oxygenates less well than parallel and series. With extreme elevations of PVR, as in primary pulmonary hypertension, parallel TAL attachment provides an oxygenating shunt around the high resistance of the NLs, thus unloading the right ventricle, normalizing CO, and maximizing oxygenation.
AB - A thoracic artificial lung (TAL) provides respiratory support for lung disease. How well a TAL improves blood oxygenation for a specific pathology depends on how the TAL is attached to the pulmonary circulation: in series with the natural lungs (NLs), in parallel, or in a hybrid series/parallel combination. A computational model, including hemodynamic and O2 and CO2 exchange components, predicts TAL effects on blood flow rates and gas transport in pulmonary disease states modeled by elevated pulmonary vascular resistance (PVR) or reduced oxygen diffusivity in the NLs. In most cases, parallel and series TAL attachment provide comparable, maximal oxygenation. Series, with passage of total cardiac output (CO) through the NLs, is preferred for its filtration of emboli. Hybrid TAL attachment is more complicated, requiring a third graft, yet oxygenates less well than parallel and series. With extreme elevations of PVR, as in primary pulmonary hypertension, parallel TAL attachment provides an oxygenating shunt around the high resistance of the NLs, thus unloading the right ventricle, normalizing CO, and maximizing oxygenation.
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U2 - 10.1097/MAT.0b013e31824cc840
DO - 10.1097/MAT.0b013e31824cc840
M3 - Article
C2 - 22543755
AN - SCOPUS:84860729762
SN - 1058-2916
VL - 58
SP - 247
EP - 254
JO - ASAIO Journal
JF - ASAIO Journal
IS - 3
ER -