@inproceedings{1ca9c5c2926d4f7fa1ffa96fe1a9930e,
title = "Preparation of multifunctional nanofibrous scaffold for tissue engineering",
abstract = "In tissue engineering, scaffolds with multiscale functionality, especially with the ability to locally release multiple or specific bioactive molecules to targeted cell types are highly desired in regulating appropriate cell phenotypes. In this study, poly (epsilon-caprolactone) (PCL) solutions (8% w/v) containing different amount of bovine serum albumin (BSA) with or without collagen were electrospun into nanofibers. As verified by protein release assay and fluorescently labeling, BSA and collagen were successfully incorporated into electrospun nanofibers. By controlling the sequential deposition and fiber alignment, 3D scaffolds with spatial distribution of collagen or BSA were assembled using fluorescently labeled nanofibers. Human dermal fibroblasts showed preferential adhesion to PCL nanofibers containing collagen than PCL alone. Taken together, multiscale scaffolds with diverse functionality and tunable distribution of biomolecules across the nanofibrous scaffold can be fabricated using electrospun nanofibers.",
keywords = "3D microenvironment, Electrospinning, Multifunctionality, Nanofibers, Tissue engineering",
author = "X. Yang and Ogbolu, {K. R.} and H. Wang",
year = "2007",
language = "English",
isbn = "1420063421",
series = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings",
pages = "684--687",
booktitle = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings",
note = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 ; Conference date: 20-05-2007 Through 24-05-2007",
}