Preparation of multifunctional nanofibrous scaffold for tissue engineering

X. Yang, K. R. Ogbolu, H. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

In tissue engineering, scaffolds with multiscale functionality, especially with the ability to locally release multiple or specific bioactive molecules to targeted cell types are highly desired in regulating appropriate cell phenotypes. In this study, poly (epsilon-caprolactone) (PCL) solutions (8% w/v) containing different amount of bovine serum albumin (BSA) with or without collagen were electrospun into nanofibers. As verified by protein release assay and fluorescently labeling, BSA and collagen were successfully incorporated into electrospun nanofibers. By controlling the sequential deposition and fiber alignment, 3D scaffolds with spatial distribution of collagen or BSA were assembled using fluorescently labeled nanofibers. Human dermal fibroblasts showed preferential adhesion to PCL nanofibers containing collagen than PCL alone. Taken together, multiscale scaffolds with diverse functionality and tunable distribution of biomolecules across the nanofibrous scaffold can be fabricated using electrospun nanofibers.

Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages684-687
Number of pages4
StatePublished - 2007
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: 20 May 200724 May 2007

Publication series

Name2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Volume2

Conference

Conference2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
Country/TerritoryUnited States
CitySanta Clara, CA
Period20/05/0724/05/07

Keywords

  • 3D microenvironment
  • Electrospinning
  • Multifunctionality
  • Nanofibers
  • Tissue engineering

Fingerprint

Dive into the research topics of 'Preparation of multifunctional nanofibrous scaffold for tissue engineering'. Together they form a unique fingerprint.

Cite this