TY - JOUR
T1 - Preparation of oxime dual NK1/NK2 antagonists with reduced NK3 affinity
AU - Reichard, Gregory A.
AU - Grice, Cheryl A.
AU - Shih, Neng Yang
AU - Spitler, James
AU - Majmundar, Sapna
AU - Wang, Steven D.
AU - Paliwal, Sunil
AU - Anthes, John C.
AU - Piwinski, John J.
PY - 2002/9/2
Y1 - 2002/9/2
N2 - By employing a stereosimplification approach, a thorough SAR exploration of the piperidine region of Sch 206272 was possible through a practical and efficient synthesis of substituted cyclic ureas. This SAR study led to the identification of a benzimidazolinone series of compounds which display single digit nanomolar NK1/NK2 affinity and near micromolar binding for the NK3 receptor.
AB - By employing a stereosimplification approach, a thorough SAR exploration of the piperidine region of Sch 206272 was possible through a practical and efficient synthesis of substituted cyclic ureas. This SAR study led to the identification of a benzimidazolinone series of compounds which display single digit nanomolar NK1/NK2 affinity and near micromolar binding for the NK3 receptor.
UR - https://www.scopus.com/pages/publications/0037009237
UR - https://www.scopus.com/pages/publications/0037009237#tab=citedBy
U2 - 10.1016/S0960-894X(02)00462-6
DO - 10.1016/S0960-894X(02)00462-6
M3 - Article
C2 - 12161132
AN - SCOPUS:0037009237
SN - 0960-894X
VL - 12
SP - 2355
EP - 2358
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 17
ER -